Registration Dossier

Ecotoxicological information

Long-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
experimental study planned
Study period:
as soon as possible after decision of ECHA
Justification for type of information:
TESTING PROPOSAL ON VERTEBRATE ANIMALS
[Please provide information for all of the points below. The information should be specific to the endpoint for which testing is proposed. Note that for testing proposals addressing testing on vertebrate animals under the REACH Regulation this document will be published on the ECHA website along with the third party consultation on the testing proposal(s).]

NON-CONFIDENTIAL NAME OF SUBSTANCE:
- Name of the substance on which testing is proposed to be carried out 2,2'-azobis[2-methylpropionamidine] dihydrochloride
- Name of the substance for which the testing proposal will be used [if different from tested substance] -/-

CONSIDERATIONS THAT THE GENERAL ADAPTATION POSSIBILITIES OF ANNEX XI OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION [please address all points below]:
- Available GLP studies
not available
- Available non-GLP studies
not available
- Historical human data
not relevant
- (Q)SAR
not available
- In vitro methods
not available
- Weight of evidence
no information regarding long-term effects to aquatic invertebrates available
- Grouping and read-across
no information from similar substances regarding long-term effects to aquatic invertebrates available
- Substance-tailored exposure driven testing [if applicable] -/-
- Approaches in addition to above [if applicable] -/-
- Other reasons [if applicable] -/-

CONSIDERATIONS THAT THE SPECIFIC ADAPTATION POSSIBILITIES OF ANNEXES VI TO X (AND COLUMN 2 THEREOF) OF THE REACH REGULATION ARE NOT ADEQUATE TO GENERATE THE NECESSARY INFORMATION:
-/-

FURTHER INFORMATION ON TESTING PROPOSAL IN ADDITION TO INFORMATION PROVIDED IN THE MATERIALS AND METHODS SECTION:
- Details on study design / methodology proposed [if relevant]

Data source

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 211 (Daphnia magna Reproduction Test)

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: granular

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
semi-static
Water media type:
freshwater
Total exposure duration:
21 d

Results and discussion

Applicant's summary and conclusion