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EC number: 221-070-0
CAS number: 2997-92-4
The study was perfomed using a HPLC with a C18
column. Six reference items with different retention times were used to
produce a calibration curve, since retention time on hydrophobic columns
and Pow are correlated. The reference items were chosen on behalf of the
First, a solution of the reference items was
analysed with HPLC, then a solution of the test item; and finally again
the solution with the reference items. Each analysis was performed three
times, totalling to nine runs.
For each reference item, the capacity factor K was
calculated from the retention time of thio urea and the retention time
of the respective reference item. A calibration function (log K versus
log Pow, linear fir) was determined using the literature values for Pow
of the reference items and the retention times in the six
The chromatogram of the test item gave one large
peak at 1.3 minutes. With the calibration function log K versus log Pow,
the corresponding log Pow was determined with: < 0.3.
The peak lies within the deadtime of the method and
not within the range of log Pows of the reference items. Therefore, the
corresponding log Pows should be stated as < 0.3. It is thus concluded
that the test item has a log Pow of < 0.3.
The partition coefficient of 2,2'-azobis[2-methylpropionamidine] dihydrochloride is stated as < 0.3. For the chemical safety assessment, a value of 0.3 was assumed.
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