Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-842-9 | CAS number: 7758-89-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
- Principles of method if other than guideline:
- BASF Test
Before OECD Guideline 404 was established in 1982, skin irritation was tested using an internal method (BASF test). White Vienna rabbits were used. 2 animals were treated for 1, 5, 15 minutes and 2 other animals for 20 hours with 80% aqueous copper chloride using occlusive conditions. An application site of 2.5 x 2.5 cm was covered with test substance on a patch. After the application time of 1, 5 and 15 minutes, the skin was washed with an aqueous Lutrol solution (50 %). - GLP compliance:
- no
Test material
- Reference substance name:
- Copper chloride
- EC Number:
- 231-842-9
- EC Name:
- Copper chloride
- Cas Number:
- 7758-89-6
- Molecular formula:
- Cl Cu
- IUPAC Name:
- λ¹-copper(1+) chloride
- Details on test material:
- - Name of test material (as cited in study report): Kupfer-I-Chlorid
- Analytical purity: 98 - 99%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.54 - 3.25 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- water
- Controls:
- no
- Amount / concentration applied:
- Concentration: 80 %
- Duration of treatment / exposure:
- 1, 5, 15 minutes and 20 hours
- Observation period:
- 8 days
- Number of animals:
- 2 per treatment
- Details on study design:
- TEST SITE: back
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- 15 min exposure
- Basis:
- mean
- Remarks:
- (2 animals)
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritation parameter:
- edema score
- Remarks:
- 15 min exposure
- Basis:
- mean
- Remarks:
- (2 animals)
- Time point:
- other: 24-72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects
- Irritation parameter:
- erythema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Remarks:
- (2 animals)
- Time point:
- other: 24-72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 d
- Remarks on result:
- other: Full thickness necrosis of the skin has been observed at the end of the observation period.
- Irritation parameter:
- edema score
- Remarks:
- 20 h exposure
- Basis:
- mean
- Remarks:
- (2 animals)
- Time point:
- other: 24-72 h
- Score:
- 2.5
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 d
Any other information on results incl. tables
The test substance led to severe skin irritation in both animals when treated for 20 hours. To evaluate the skin irritation potential of the test substance, the scores of the 20 hour incubation have been used, but the scores for the 15 min incubation have been also taken into account. Based on the mean values calculated for the 20-hour exposure, the substance has to be judged as highly irritant to skin. As full thickness necrosis of the skin has been observed, the test substance is corrosive to the skin.
Animal |
Readings |
Exposure period: 15 minutes |
||
Erythema |
Edema |
Additional findings |
||
01 |
24 h |
0 |
0 |
|
72 h |
0 |
0 |
|
|
Mean score |
0 |
0 |
|
|
02 |
24 h |
0 |
0 |
|
72 h |
0 |
0 |
|
|
Mean score |
0 |
0 |
|
Animal |
Readings |
Exposure period: 20 hours |
||
Erythema |
Edema |
Additional findings |
||
01 |
24 h |
2 |
3 |
parchment-like necrosis |
72 h |
2 |
3 |
hard, relocatable necrosis |
|
8 d |
- |
- |
hard, relocatable necrosis |
|
Mean score |
2 |
3 |
|
|
02 |
24 h |
2 |
2 |
parchment-like necrosis |
72 h |
2 |
2 |
leather-like necrosis |
|
8 d |
- |
- |
leather-like necrosis |
|
Mean score |
2 |
2 |
|
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.