Registration Dossier
Registration Dossier
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EC number: 244-599-9 | CAS number: 21829-50-5
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Tris[(2-hydroxyethyl)ammonium] citrate is characterised as “readily biodegradable”.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
No data on biodegradation screening is available for tris[(2-hydroxyethyl)ammonium] citrate. Tris[(2 -hydroxyethyl)ammonium] citrate is the salt of monoethanolamine and citric acid. Monoethanolamine and citric acid are the starting materials for the synthesis of tris[(2-hydroxyethyl)ammonium] citrate, and the only difference is that in tris[(2-hydroxyethyl)ammonium] citrate the substances are present in its protonated form as a monoethanolammonium cation and as its deprotonated form as a citric acid anion. It is expected that the ecotoxicological properties of tris[(2-hydroxyethyl)ammonium] citrate shall be governed by the properties of monoethanolamine and citric acid (for more details see reporting format for the analogue approach in Appendix A.2).
A non-GLP OECD guideline 301A (DOC Die-Away test) is available for monoethanolamine. After 21 days >90% degradation based on DOC removal was observed for monoethanolamine (BASF, 1995). Monoethanolamine is therefore characterized as being ready biodegradable.
For citric acid three studies are available, one according OECD guideline 301B (DOC CO2 Evolution test), one according to OECD guideline 302B (Zahn-Wellens Test) and one according to OECD guideline 301E (Modified OECD Screening Test) (Gerike and Fischer, 1979). In the CO2 Evolution Test 97% degradation was observed after 28 days (as CO2 evolution), in the Zahn-Wellens test 85% degradation was observed after 14 days (as DOC removal) and in the Modified OECD Screening Test 100% degradation was observed after 19 d (as DOC removal). Citric acid is therefore characterized as being ready biodegradable.
It can be concluded that also tris[(2-hydroxyethyl)ammonium] citrate is readily biodegradable.
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