1-Naphthalenamine, 1,2,3,4-tetrahydro-, (1R)-

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: GLP guideline study with analytical monitoring. The study was terminated since none of the analytical values were in the required range.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Report date:

2010

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

1,2,3,4-tetrahydro-1-naphthylamine

EC Number:

218-712-7

EC Name:

1,2,3,4-tetrahydro-1-naphthylamine

Cas Number:

2217-40-5

IUPAC Name:

1,2,3,4-tetrahydronaphthalen-1-amine

Details on test material:

- Batch number: 7346-05167 Hauptlauf
- Purity: 98.2 area-% (report No.: 05L00169)

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

not specified

Details on test solutions:

- Preparatio of test solution: The test substance (100 mg/L) was stirred for approx. 10 min at 20 ± 2°C. The stock solution was clear and colorless. The test substance concentrations were prepared by dilution of a stock solution of 100 mg/L.

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

TEST ORGANISM
- Common name: Water flea
- Age at study initiation: < 24 hours

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test conditions

Nominal and measured concentrations:

- Nominal concentrations: 0 (control), 0.781, 1.56, 3.13, 6.25, 12.5, 25, 50, 100 mg/L based on test substance mass without correction for purity.

Details on test conditions:

TEST SYSTEM
- Test vessel fill volume: 10 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration: 4
- No. of vessels per control: 4

EFFECT PARAMETERS MEASURED: Mobility

TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2
- Range finding study: Yes, the concentrations for the study were selected based on a range finding test where the 48-h EC50 was 10 - 100 mg/L.

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

EC0

Effect conc.:

12.5 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 2

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

12.5 - 25 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Effect concentrations 3

Duration:

48 h

Dose descriptor:

EC100

Effect conc.:

50 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Any other information on results incl. tables

The analytically determined concentration of the test substance in the stock solution was 4.58 mg/L (4.6% of the nominal value) at start of exposure, the analytical values in the test concentrations at start of exposure were in a range of 0 - 5.7% of the nominal concentration.