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EC number: 203-874-3
CAS number: 111-48-8
Cytogenetic summary tableDose in mg/kg bw % MPE (SE) PE/NE ratio (SE)and harvest timevehicle 24 h 0.13 (0.02) 0.91 (0.03)vehicle 48 h 0.09 (0.01) 0.84 (0.06)500 24 h 0.09 (0.03) 0.79 (0.03) 1000 24 h 0.12 (0.03) 0.79 (0.04) 2000 24 h 0.11 (0.02) 0.82 (0.05)2000 48 h 0.10 (0.02) 0.91 (0.04) positivecontrol 24 h 3.07 (0.35)** 0.67 (0.04)* SE: standard error; *: p<0.05; **: p<0.01
Guideline study with acceptable restrictions (no details about the test
In the mouse bone marrow micronucleus assay 6 male mice per dose were
gavagaed once with 0, 500, 1000, or 2000 mg/kg and bone marrow prepared
for evaluation 24 and 48 h after application. No increase in the
frequency of micronuclei was detected. No clinical toxicity or cytotoxic
effects on the bone marrow were found even at 2000 mg/kg bw, the highest
test dose recommended by the current guideline. The positive controls
Conclusion: No mutagenic activity in the mouse bone marrow micronucleus
test at dose levels up to 2000 mg/kg bw.
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