Registration Dossier

Administrative data

Description of key information

A documentation and evaluation of available data on this endpoint is presented in:
Thiodiglycol, SIDS Initial Assessment Report for SIAM 19, final version 10/2006.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Acute dermal irritation was tested on rabbits according to OECD guideline 404 (Elf Aquitaine 1995). A very slight erythema was noted in 1 out of 3 animals 1 hour after treatment until day 4. The effect was completely reversible within 5 days. No cutaneous reactions were observed in the other 2 animals. The chemical can therefore be considered as not irritating to the skin. In a 2nd study (BASF 1966) only slight reddening of the skin was detected in rabbits after occlusive dermal exposure to the undiluted test substance for 20 h (worst case scenario).

Conclusion: Thiodiglycol is not irritating to the skin.

In a GLP study according to OECD guideline 405 only slight irritation of the eye was observed (Elf Aquitaine 1995); 0.1 ml undiluted thiodiglycol applied to the eyes of 3 rabbits resulted in no effects on cornea and iris, but slightly affected the conjunctivae of 2 rabbits. In an early study (BASF AG 1966), 50 μl of the undiluted test substance was applied to the conjunctival sac of one eye of each of 2 rabbits (not rinsed). Effects were described 24, 48, and 72 hours as well as 6 and 8 days after treatment. The 1st rabbit showed slight conjunctival redness (Draize score 1 at 24 - 72 hours) and moderate (Draize score 2 at 24 hours) to slight (Draize score 1at 48 hours) conjunctival chemosis, slight corneal opacity (Draize score 1 at 24 hours up to day 6) but no iritis. All effects were reversible at day 8 (study end). In the 2nd rabbit no effects were detected except a slight redness (Draize score 1) 24 and 48 hours after instillation.

Conclusion: Thiodiglycol is slightly irritating to the rabbit eye.


Effects on eye irritation: slightly irritating

Justification for classification or non-classification

Thiodiglycol is irritating to the rabbit eye. Therefore, classification with R36 is warranted according to EU Directive 67/548/EEC and with H319 (cat. 2) according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.