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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: older study; non GLP

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Report date:
1957

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl cyclohexane-1,4-dicarboxylate
EC Number:
202-347-5
EC Name:
Dimethyl cyclohexane-1,4-dicarboxylate
Cas Number:
94-60-0
Molecular formula:
C10H16O4
IUPAC Name:
1,4-dimethyl cyclohexane-1,4-dicarboxylate

Test animals

Species:
rat

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
whole body
Vehicle:
air
Duration of exposure:
6 h
Concentrations:
0.97 mg/L (117 ppm); 2.91 mg/L (355 ppm)
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
airflow through compartment was 2L/min at either room temperature (117 ppm) or 100 deg. C (355 ppm)

Results and discussion

Preliminary study:
Atmospheric concentration of 2.91 mg/L of DMCD for 6 hours caused no symptoms or adverse effects
Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 2.91 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
6 h

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Atmospheric concentration of 2.91 mg/L of DMCD for 6 hours caused no symptoms or adverse effects
Executive summary:

In an acute inhalation experiment, 3 rats were exposed to a chamber concentration of 0.97 mg/L (117 ppm) for 6 hours, and a separate group of 3 rats were exposed to a chamber concentration of 2.91 mg/L (355 ppm) for 6 hours. At the end of the exposure period, there were no symptoms or adverse effects observed.