Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
2010
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In silico prediction.

Tox Boxes 2.9 is the in house software for the prediction of basic toxicity endpoints in chemicals. Predictions are made analyzing the chemical structure and based upon large validated databases and QSAR models, in combination with expert knowledge of organic chemistry and toxicology.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1-(2,3-dichlorophenyl)piperazine hydrochloride
EC Number:
601-621-5
Cas Number:
119532-26-2
Molecular formula:
C10H13Cl3N2
IUPAC Name:
1-(2,3-dichlorophenyl)piperazine hydrochloride

Test animals

Species:
other: mouse and rats

Administration / exposure

Route of administration:
other: Intraperitoneal, intravenous, subcutaneous administrations

Results and discussion

Any other information on results incl. tables

Acute toxicity shows values with borderline and moderate reliability index.

Applicant's summary and conclusion

Conclusions:
Acute toxicity shows values with borderline and moderate reliability index.