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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
abstract

Data source

Reference
Reference Type:
publication
Title:
Mutagenicity characteristics of 255 environmental chemicals.
Author:
Kubo T, Urano K, Utsumi H
Year:
2002
Bibliographic source:
J Health Sci 48(6): 545–554.

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2,4-trichlorobenzene
EC Number:
204-428-0
EC Name:
1,2,4-trichlorobenzene
Cas Number:
120-82-1
Molecular formula:
C6H3Cl3
IUPAC Name:
1,2,4-trichlorobenzene
Test material form:
not specified

Results and discussion

Test resultsopen allclose all
Species / strain:
S. typhimurium TA 97
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Species / strain:
S. typhimurium TA 100
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
Interpretation of results: negative
Executive summary:

The result of the salmonella mutagenicity test of 1,2,4-TCB for both strains TA97 and TA100 were negative