Registration Dossier

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

Workers - Hazard for the eyes

Additional information - workers

General Population - Hazard via inhalation route

Systemic effects

Acute/short term exposure
DNEL related information

Local effects

Acute/short term exposure
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard via oral route

Systemic effects

Acute/short term exposure
DNEL related information

General Population - Hazard for the eyes

Additional information - General Population

LD50(rat), oral:   > 2000 mg/kg b.w.   (OECD 423 / EC B.1, GLP); limit test

Skin irritation: not irritant (in vitro“Interleukin-1α, GLP)

Eye irritation: not irritant ( in vitro “HET-CAM”)

Skin sensitisation:  not sensitising (OECD 429 / EC B.42, GLP); LLNA

in vitro: Gene mutation (Bacterial reverse mutation assay / Ames test): S. typhimurium TA 1535, TA 1537, TA 98 and TA 100, TA102 negative with and without metabolic activation; Concentration range in the main test (experiment I: 3, 10, 33, 100, 333, 1000, 2500 and 5000 µg/plate and experiment II: 33, 100, 333, 1000, 2500 and 5000 µg/plate, according to OECD 471.