Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008-11-27 to 2008-12-03
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP, guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2009
Report Date:
2009

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
, 1995
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
, 1992
Deviations:
no
GLP compliance:
yes (incl. certificate)
Remarks:
signed 2006-06-01
Type of method:
flask method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Naringin dihydrochalcone (DHC)
- Physical state: solid, whitish powder
- Storage condition of test material: room temperature, dry and dark
No further details are given.

Results and discussion

Water solubilityopen allclose all
Water solubility:
0.111 g/L
Temp.:
10 °C
pH:
4
Water solubility:
0.116 g/L
Temp.:
10 °C
pH:
6.96
Water solubility:
0.735 g/L
Temp.:
10 °C
pH:
8.49
Water solubility:
0.236 g/L
Temp.:
20 °C
pH:
4
Water solubility:
0.273 g/L
Temp.:
20 °C
pH:
6.98
Water solubility:
1.33 g/L
Temp.:
20 °C
pH:
8.46
Water solubility:
0.493 g/L
Temp.:
30 °C
pH:
3.93
Water solubility:
0.59 g/L
Temp.:
30 °C
pH:
6.98
Water solubility:
2.66 g/L
Temp.:
30 °C
pH:
8.47
Details on results:
A temperature and pH dependence of the solubility of the test item was observed. The solubility was higher at higher temperatures and pH values. For details see attachments.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): moderately soluble (100-1000 mg/L) at 20°C and pH 7: 273 mg/L
A temperature and pH dependence of the solubility of the test item was observed. For details see attachments.