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EC number: 201-832-9
CAS number: 88-45-9
On the basis of the experimental
studies of the structurally and functionally similar read across
chemical and applying the weight of evidence approach, the hydrolysis
half-life value of the test chemical can be expected to be > 5 days, at
pH range 4, 7 & 9 and a temperature of 50°C or 276 days at pH 7.0,
respectively. Thus, based on this half-life value, it can be concluded
that the test chemical is not hydrolysable in water.
Data available for the structurally
and functionally similar read across chemicals has been reviewed to
determine the half-life of the test chemical. The studies are as
The half-life of the test chemical was
determined at different pH range. The study was performed according to
OECD Guideline 111 (Hydrolysis as a Function of pH) at a temperature of
50°C (ranges from 49-51°C) and pH of 4, 7 and 9, respectively. Initial
test chemical concentration used for the study was 100 mg/l. Experiment
was performed in 2 replicates. The test substance has no activity of
hydrolysis and thus was reported to be hydrolytically stable at pH 4, 7
and 9, respectively at a temperature of50⁰C for 5 days. The half-life
value of test chemical was determined to be > 5 days at pH 4, 7 and 9,
respectively & at a temperature of 50⁰C. Thus based on this, test
chemical is considered to be not hydrolysable.
In an another study, the half-life and
hydrolysis rate constant was determined of the test chemical. The
hydrolysis rate constant of test chemical was determined to be 2.9 х 109
L/mol-sec with a corresponding half-lives of 276 days at pH 7,
respectively. Based on the half-life value, it is concluded that the
test chemical is not hydrolysable.
For the test chemical, the half-life
of the test chemical was determined at different pH range. The
preliminary study was performed according to OECD Guideline 111
(Hydrolysis as a Function of pH) at a temperature of 50°C. Initial test
chemical conc. Used for the study was 20 mg/l. Analytical method involve
the use of HPLC. Although the half-life value of test chemical was not
known, but at the preliminary test, the residues of the test chemical
were more than 90 % in all the pH. Thus, the test chemical was reported
to be stable in water at a temperature of 50⁰C and at pH 4, 7 and 9,
respectively. Based on this, it is concluded that the test chemical is
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