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EC number: 212-769-1
CAS number: 868-14-4
The following organs were weighed at autopsy: adrenals, bladder, brain,
heart, kidneys, liver, lung, prostate, spleen, stomach, testes, and
thyroid. The histologic changes observed in the experimental groups were
similar to those seen in the control group. Mild focal pyelonephritis,
moderate congestion, mild hyperplasia of tubular epithelium, and
occasionai protein casts and hyaline droplet' degeneration were noted in
the kidneys, while livers of rabbits in ali groups exhibited
pericholangitis, bile duct proliferation, and dilatation as well as
moderate congestion. These changes are not unusual in rabbits and are
not to be attributed to the experimental feeding.
Examination of the testes revealed that the seminiferous tubules, the
interstitial cells, and spermatogenesis were normal in all groups.
Slight peritubular fibrosis and mild stromal hyalinization were observed
in each group after 150 days of feeding.
The effects of sodium tartrate when fed to rabbits for 150 days at
concentrations equivalent to 5.0% of the organic acid in the diet were
investigated. Particular attention was given to the possible appearance
of testicular toxicity. No significant gross or histopathologic changes
attributable to the experimental feeding could be found in any case.
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