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EC number: 212-769-1
CAS number: 868-14-4
The retention of radioactivity in the kidneys of rats dosed with
L(+)-tartrate was much less than in those of rats dosed with
DL-tartrate. And furthermore, L(+)-tartrate in kidneys was mainly in
soluble manner, whereas DL-tartrate was present as more insoluble
This study reported were carried out to compare the distribution of
radioactivity in the bones and kidneys of rats administered relatively
high repeated oral doses of monosodium L(+)-[14C]tartrate or
DL-[14C]tartrate. At 3 h after the last dose of L(+)-tartrate, the
radioactivity was mainly present in the gastrointestinal tract, liver,
kidneys and bone. L(+)-[14C] tartrate was not retained in the kidneys
(1287±118 ppm at 6 h, n = 8) when administered to rats for 7 days at a
dose level of 2.73 g/kg/day, and the initial decline of plasma
concentrations of radioactivity was more rapid (t0.5approx.3 h). For
this reason, monosodium L (+)-tartrate was non-toxic at 2.73 g/kg/ day
whereas monosodium DL-tartrate was toxic at this dosage.
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