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EC number: 412-300-2
CAS number: 139504-68-0
One key study is available on the bioaccumulation of Amber Core on Carp (Cyprinus
carpio). This study was performed in a flow through system under GLP
and according to the "Method for Testing the Degree of Accumulation of
Chemical Substances in Fish Body" stipulated in the "Testing Methods for
New Chemical Substances" (July, 1974) and is based on OECD Guideline
305C (May, 1981).
An acute toxicity test was performed before the bioaccumulation test.
This preliminary test result for 48 -hour LC50 (=9.95 mg/L) was used to
decide on the test concentrations of the test substance in the
bioaccumulation study. Two test medium concentration levels were used:
0.050 mg/L and 0.0050 mg/L. The temperature of test water was maintained
at 25 +/- 2°C with concentrations of dissolved oxygen in test tank
comprised between 6.4 and 7.8 mg/L (corresponding to >60% saturation).
15 fish were used in Level 1 and 2 and 5 fish were used in control (the
control was set as a blank test). The duration of exposure was 8 weeks.
2 peaks on the mass fragmentogram were detected by GC-MS. The peaks were
named peak A and B in the elution order respectively. The concentrations
of test substance were analyzed by GC-MS. BCFs of the test substance
were estimated to have reached equilibrium after 8 weeks. The
bioaccumulation potential of test substance in carp was an approximately
similar value at both levels.
However, to consider the worst case, the value used for chemical safety
assessment was the highest BCF obtained: 173.
Furthermore, the partition coefficient of Amber Core was estimated using
a QSAR calculation and the corresponding mean of 3.81 was retained as
key value. Additionally, to provide supplementary evidence, the
bioconcentration factor was also estimated using QSAR calculations. With
EPI Suite – BCFBAF v3.01, the BCF was comprised between 218.8 L/Kg and
304.1 L/Kg. With the CAESAR model, the BCF was estimated to be 27 L/Kg.
It is assumed that the affinity of the substance for the lipids of an
organism is insufficient for it to be considered bioaccumulative.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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