Registration Dossier

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
PNEC aqua (freshwater)
PNEC value:
0.003 mg/L
Assessment factor:
100
Extrapolation method:
assessment factor

Marine water

Hazard assessment conclusion:
no hazard identified

STP

Hazard assessment conclusion:
no data: aquatic toxicity unlikely

Sediment (freshwater)

Hazard assessment conclusion:
PNEC sediment (freshwater)
PNEC value:
11.7 mg/kg sediment dw
Extrapolation method:
equilibrium partitioning method

Sediment (marine water)

Hazard assessment conclusion:
no exposure of sediment expected

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
PNEC soil
PNEC value:
2.3 mg/kg soil dw
Extrapolation method:
equilibrium partitioning method

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusion on classification

2-(diphenylphosphino)benzoic acid is acutely toxic to freshwater fish (rainbow trout) with a 96h LC50 value of 200 mg/L and acutely toxic to invertebrates (daphnia magna) with a 48h EC50 value of 3.7 mg/L. The substance has also been tested for chronic toxicity to freshwater invertebrates (daphnia magna) which resulted in 21d LC50 and NOEC values of 0.7 mg/L and 0.32 mg/L, for effects on mortality, reproduction and growth.

Although the acute toxicity data for fish and invertebrates is above the predicted water solubility limit for the substance (0.3-1.4 mg/L), the observed toxicity could be attributed to a combination of the test item and the oxide transformation product (2-(diphenylphosphino)benzoic acid oxide) which is predicted to be more soluble in water (79-764 mg/L according to EPISUITE WSKOWWIN and WATERNT).

2-(diphenylphosphino)benzoic acid (and the transformation product 2-(diphenylphosphino)benzoic acid oxide) are not expected to be readily or inherently biodegradable based on QSAR and

publicly available data (OSPAR, 2000) for structurally analagous substances (Triphenyl phosphine; CAS: 603-35-0 and Triphenylphosphine oxide; CAS: 791 -28 -6)

2-(diphenylphosphino)benzoic acid has a log Kow value of 2.9 at pH 2.0 (non-ionised netural form) and a predicted fish BCF value of 36 L/Kg. Both of these values are below the log Kow 4.0 and BCF 500 threshold limits for classification as potentially bioaccumulative.

Thus, in accordance with Classification, Labelling and Packaging (CLP) Regulation ((EC) No 1272/2008, 2-(diphenylphosphino)benzoic acid meets the requirements for classification as H411: chronic category 2 (toxic to the environment with long lasting effects).