Registration Dossier
Registration Dossier
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EC number: 201-497-9 | CAS number: 83-73-8
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- RTECS Number : VC5775000
- Author:
- RTECS handbook
- Year:
- 2 012
- Bibliographic source:
- RTECS (Registry of Toxic Effects of Chemical Substances); LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 1,261,1966
- Reference Type:
- other: Authoritative data base
- Title:
- GCID: 477779
- Author:
- ACToR database
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource); Lancet. Vol. 1, Pg. 261, 1966.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS ,SAX handbook and ACToR database.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diiodohydroxyquinoline
- EC Number:
- 201-497-9
- EC Name:
- Diiodohydroxyquinoline
- Cas Number:
- 83-73-8
- Molecular formula:
- C9H5I2NO
- IUPAC Name:
- 5,7-diiodoquinolin-8-ol
- Details on test material:
- - Name of test material: diiodohydroxyquinoline
- Molecular formula: C9H5I2NO
- Molecular weight: 396.95
- Substance type: organic
- Physical state: solid
Constituent 1
Test animals
- Species:
- other: Human
- Strain:
- other: not applicable
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 2 years
- Frequency of treatment:
- intermittent frequency
Results and discussion
Effect levels
- Dose descriptor:
- other: TDLo
- Effect level:
- 120 000 other: mg/kg
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Sense Organs and Special Senses (Eye) - visual field changes
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Repeated dose oral toxicity value of diiodohydroxyquinoline to Human - child was found to be TDLo(Lowest published toxic dose): 120000 mg/kg, when diiodohydroxyquinoline was administered orally for 2 years.
- Executive summary:
Repeated dose oral toxicity value of diiodohydroxyquinoline to Human - child was found to be TDLo(Lowest published toxic dose): 120000 mg/kg, when diiodohydroxyquinoline was administered orally for 2 years.
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