trans-crotonic acid

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1967

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: short summary, non GLP, no guideline followed

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Report date:

1967

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

4 h whole body exposure to an unknown air concentration of the test substance.

GLP compliance:

no

Remarks:

Study performed prior to implementation of GLP

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

trans-crotonic acid

EC Number:

203-533-9

EC Name:

trans-crotonic acid

Cas Number:

107-93-7

Molecular formula:

C4H6O2

IUPAC Name:

but-2-enoic acid

Test animals

Species:

other: rats (wistar) and guinea pig

Sex:

female

Details on test animals or test system and environmental conditions:

no data

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION

- Exposure chamber volume: 28 L
- Method of conditioning air: 24.5 g of the product was vapoured at 125-130°C, Airflow: 500 liter/hour
- Temperature in air chamber: 29°C

Duration of exposure:

4 h

Concentrations:

less than 1.2 mg/L, exact concentration unknown (the evaporated test item recrystallised partly before the vapour reached the inhalation chamber)

No. of animals per sex per dose:

5 rats and 5 guinea pigs

Details on study design:

- Duration of observation period following administration: 7 days

Results and discussion

Effect levels

Key result

Sex:

female

Dose descriptor:

LC0

Effect level:

> 0.9 - < 1.2 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Remarks on result:

other: rats and guinea pigs were tested; actual exposure concentration unknown as the evaporated test item recrystallised partly before the vapour reached the inhalation chamber

Mortality:

no

Clinical signs:

other: no

Body weight:

no data

Gross pathology:

no data

Other findings:

no data

Any other information on results incl. tables

Based on the equation for saturated vapour concentrations it can be estimated that the concentration of the substance is approx. 0.88 mg/L saturated air at 20 °C. Therefore, it is assumed that at a temperature of 29 °C the test item concentration was between 0.88 and 1.2 mg/L.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Conclusions:

Under the conditions of the present acute toxicity study the inhalation of the test item crotonic acid showed no abnormal behaviour in rats and guinea pigs.