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EC number: 263-372-5
CAS number: 62010-10-0
be updated with numbers for each parameter)
Oestrous cycle, reproductive parameters,
pairing combination and mating performance:
- Measurements of oestrous cycle, pre-coital
intervals, copulatory and fertility indices did not show differences
between treated and control groups.
Implantation, pre-birth loss data and
gestation length of females:
- No significant differences were found in
the number of implantations, corpora lutea, total litter size,
pre-implantation loss and pre-birth loss between control and treated
groups. Gestation periods were similar between groups. The majority of
females gave birth on Day 22 post coitum.
Litter data at birth, on Day 1 and on Day 4 post
partum of females and sex ratio of pups:
- Mean pup weights were found comparable
between groups at birth and on Day 4 post partum. Sex ratio did
not differ between groups.
Clinical signs of pups: samll pups were generally
observed in all groups including controls. Cold to touch and/or apparently
no food intake were also occasionally recorded in all groups. One pup of low
dose group showed absence of tail. This abnormality was considered incidental.
Necropsy findings in decedent pups and in
pups sacrificed on Day 4 post partum:
- The majority of decedent pups had
autolysed organs in the abdominal cavity at necropsy. No abnormalities
were found in pups sacrificed on Day 4 post partum with the
exception of the low dose pup with the absence of tail. One pup of the
mid-dose group showed no milk in stomach.
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