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EC number: 263-372-5
CAS number: 62010-10-0
In two in vivo skin irritation studies, zirconium basic sulfate was found not to be irritating to rabbit skin. Both studies were performed according to OECD guideline 404 (Clouzeau, 1994; Cuthbert and Jackson, 1992b).In an ocular irritation test, performed according to OECD Guideline 405, zirconium basic sulfate was found not to be irritating to rabbit eyes (de Jouffrey, 1995).
Two skin irritation studies were performed in New Zealand White
rabbits. Both studies were included in a weight of evidence approach. In
the study of Clouzeau (1994, Klimisch 1), the dermal irritancy potential
of zirconium basic sulfate was investigated by a semi-occlusive
application of the test substance to the left (3 minutes) and right (1
and 4 hours) side of a New Zealand White rabbit (animal 1). Based on the
results of animal 1 (product not very irritating), 2 other animals were
tested. After 4 hours of exposure, the test substance was removed with a
dry gauze. Erythema and edema were scored based on the Draize scoring
system at 1, 24, 48 and 72 hours after removal of the test substance.
Erythema score for animal 1 was 0.3 and fully reversible within 48
hours; for animals 2 and 3 the score was 0. The mean edema score for the
3 animals was 0. The skin irritation study of Cuthbert and Jackson
(1992b, Klimisch 2) yielded similar observations. No skin reactions were
noted following semi-occlusive applications of the test material to the
skin of 3 rabbits for periods of 3 minutes, 1 and 4 hours. Under the
conditions of these tests, zirconium basic sulfate was observed to be
not irritating to rabbit skin.
In the Klimisch 1 key study, de Jouffrey (1995) investigated the eye
irritation potential of zirconium basic sulfate in 3 New Zealand White
rabbits. 100 mg of the test substance was instilled in rabbit eye. 1,
24, 48 and 72 hours after substance administration rabbit eyes were
scored for chemosis, conjunctival redness, iris and cornea according to
the Draize score. The mean result for chemosis for animals 1 to 3 was 0,
0 and 0.3 respectively. The latter score was reversible within 48 hours.
The mean score for conjunctiva for animals 1 to 3 was respectively 1,
0.7 and 1 and scores were fully reversible within 72 hours. The mean
iris and cornea score for the 3 animals was 0. Under the experimental
conditions of this test, zirconium basic sulfate was considered
non-irritant when administered by ocular route in rabbits.
Based on the test results and the criteria of the CLP Regulation,
zirconium basic sulfate should not be classified for skin or eye
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