Registration Dossier
Registration Dossier
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EC number: 224-536-1 | CAS number: 4402-30-6
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
With high probability acutely not harmful to aquatic invertebrates.
Key value for chemical safety assessment
Additional information
Experimental data on the acute toxcity to aquatic invertebrates are available for 1,1'-(methylimino)dipropan-2 -ol (CAS 4402 -30 -6). However, these data are from a screening test according to OECD 202 with a lower number of test concentrations and a higher spacing factor between test concentrations. Daphnia magna were exposed for 48 h in a static immobilisation test according to OECD 202. The 48 -h EC50 was greater than 100 mg/L (BASF SE, 2012; report no. 50E0383/11E124). The test concentration were not analytically verified but are assumed stable based on the low biodegradability potential, the high water solubility, the low adsorption potential and the low Henry's Law constant. The initial pH of the highest test concentration (100 mg/L) was slightly outside the prescribed range of the OECD TG 202 (pH 6 to 9). Therefore, this test level was also studied after pH-adjustment to pH 8.1. However, the Daphnids were not immobilised in none of the test solutions.
In addition to this screening test, experimental data from two structurally similar substances are used to support the toxicity assessment.
1,1'-nitrilotripropan-2 -ol (CAS 122 -20 -3) was tested according to Directive 79/831/EEC, Annex V, Part C (C.2 method). In the static test, Daphnia magna was exposed to a series of test solutions for 48 hours. Analytical monitoring was not performed; however, the test concentrations are assumed to be stable as the substance is sufficiently soluble in water, has a low potential for adsorption and a low Henry's Law constant. The 48 -h EC50 was determined to be >500 mg/L (nominal; BASF AG, 1981; report no. 1/1133/2/87 -1133/87).
Further information on the acute toxicity to aquatic invertebrates, are available for 1,1'-iminodipropan-2 -ol (CAS 110 -97 -4). The test followed Directive 79/831/EEC, Annex V, Part C (C.2 method). In the static test , Daphnia magna was exposed to a series of test solutions for 48 hours. Analytical monitoring was not performed; however, the test concentrations are assumed to be stable as the test substance is miscible with water, has a low potential for adsorption and a low Henry's Law Constant. The 48-h EC50 was determined to be 277.7 mg/L (nominal; BASF AG, 1981; report no. 1/1132/2/87-1132/87).
Based on the available data, the substance is assessed to be acutely not harmful to aquatic invertebrates with high probability.
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