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Short-term toxicity to aquatic invertebrates

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Description of key information

The 48 -h EC50 value is  25.9 mg/L (nominal) in aquatic invertebrates (Daphnia magna).

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
25.9 mg/L

Additional information

The toxicity of 1,2,3,4 -tetrahydroisoquinoline to aquatic invertebrates was examined in a GLP-compliant study according to OECD guideline 202. In this study, Daphnia magna (4 replicates of 5 animals per concentration) were exposed to nominal concentrations of 6.25, 12.5, 25, 50 and 100 mg/L and a blank control for 48 hours. Nominal concentrations were analytically verified at the start and at the end of the test. As test substance recoveries ranged from 90 -102%, effect concentrations are expressed as nominal. At the start of the test and after 24 and 48 hours each test vessel was visually checked for immobilised daphnids. In addition any abnormal behaviour or appearance was documented. After 48 hours no immobilisation was noted at the lowest test concentration of 6.25 mg/L. At test concentrations of 12.5 and 25 mg/L immobilisation was observed in 17/20 and 15/20 daphnids, respectively. At the highest test concentrations of 50 and 100 mg/L all animals were immobile. No additional adverse effects or abnormal behaviour were observed in any of the test treatments. Based on these findings, the 48 -h EC50 value is determined at 25.9 mg/L (nominal).