Registration Dossier
Registration Dossier
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EC number: 210-557-3 | CAS number: 618-62-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- secondary source
- Title:
- IUCLID DATAFILE
- Author:
- unknown
- Year:
- 2 000
- Bibliographic source:
- Esis-Database, European Chemicals Bureau
Materials and methods
Test guideline
- Guideline:
- EU Method B.13/14 (Mutagenicity - Reverse Mutation Test Using Bacteria)
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 3,5-dichloronitrobenzene
- EC Number:
- 210-557-3
- EC Name:
- 3,5-dichloronitrobenzene
- Cas Number:
- 618-62-2
- Molecular formula:
- C6H3Cl2NO2
- IUPAC Name:
- 1,3-dichloro-5-nitrobenzene
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: S. typhimurium TA 1535, TA 1537, TA 1538, TA 98 and TA 100
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 rat liver
- Test concentrations with justification for top dose:
- 12,5; 25; 50; 100; 200
Results and discussion
Test results
- Species / strain:
- E. coli, other: S. typhimurium TA 1535, TA 1537, TA 1538, TA 98 and TA 100
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
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