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EC number: 279-211-7 | CAS number: 79665-24-0
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable method, meets basic scientific principles
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Principles of method if other than guideline:
- Estimation of results of OECD screening tests on ready biodegradation in water: CATALOGIC (v5.11.5) BOD 28 days MITI (OECD 301C) v06.07
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 0.37
- Sampling time:
- 28 d
- Details on results:
- Model domain similarity:
- Parametric domain: 100%
- Structural domain: 25% (75% unknown)
- Mechanistic domain: 100% - Interpretation of results:
- other: not readily biodegradable (according to OECD criteria)
Reference
Description of key information
Not readily biodegradable (according to OECD criteria).
Key value for chemical safety assessment
Additional information
Data on the ready biodegradability of the described 'red disazo pigment' are not available. However, two model calculations were conducted to assess the biodegradability in a weight of evidence. The EPI Suite v4.10 (BIOWIN Program v4.10) calculation resulted in "not readily biodegradable". Additionally, the biodegradation was calculated by using CATALOGIC v5.11.5 (BOD 28 days MITI (OECD 301C) v06.07). It resulted in ca. 0.37 % biodegradation after 28 d. Even though the structural domain was correct with only 25 % (75% unknown) the results support the overall conclusion in the weight of evidence.
Moreover, the 'red disazo pigment' is practically insoluble and therefore considered to be essentially not bioavailable. Due to the large molecular size, cellular uptake of the pigment is unlikely. Hence intracellular biodegradation, which is the main degradation route of bacteria, is probably low. It can be concluded that the substance is likely to persist in the environment. For this reason no ready or inherent degradation studies are proposed.
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