Tidigare/resultat
Tidigare/resultat
Tidigare/resultat
This page provides the list of testing proposal consultations for which the deadline for comments has passed. ECHA addresses all third-party contributions in the dossier evaluation decisions addressed to the registrant.
To see if testing proposals submitted by registrants, and for which ECHA has held a third-party consultation, were subsequently withdrawn, please consult the table below. First, follow the link to the related aggregated registration dossier (if it is already published). There you can review the details of the testing proposed and other information on the substance that is subject to the testing proposal. The admissibility of any testing proposal will be concluded only after the third party consultation. Later during the testing proposal examination process, you may check the same section in the disseminated dossier to see if a testing proposal previously present has been withdrawn. The reasons for withdrawal may be that the registrant has reviewed their assessment or has taken into account the third-party comments provided to ECHA and communicated to them.
1,1'-methylenebis(4-isocyanatobenzene) and its oligomeric reaction products with butane-1,3-diol, 2,2'-oxydiethanol and propane-1,2-diol | 701-173-1 | - | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC 202-966-0) | 01/04/2022 | 16/05/2022 | Details | |
1,1'-methylenebis(4-isocyanatobenzene) and oligomeric reaction products of 1,1'-methylenebis(4-isocyanatobenzene) and oxydipropanol and oligomerization reaction products of oxydipropanol | 701-041-3 | - |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation |
16/06/2022 16/06/2022 16/06/2022 |
01/08/2022 01/08/2022 01/08/2022 |
Details | |
1,1,1,2,2,4,5,5,5-nonafluoro-4-(trifluoromethyl )-3-pentanone | 436-710-6 | 756-13-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
22/04/2021 22/04/2021 |
07/06/2021 07/06/2021 |
Details | |
1,1,1,3,3,3-hexamethyldisilazane | 213-668-5 | 999-97-3 |
Reproductive toxicity (extended one-generation reproductive toxicity study)|| Note: testing proposed with Hydroxytrimethylsilane (EC no. 213-914-1) Reproductive toxicity (pre-natal developmental toxicity)|| Note: testing proposed with Hydroxytrimethylsilane (EC no. 213-914-1) |
16/06/2022 16/06/2022 |
01/08/2022 01/08/2022 |
Details | |
1,1,1,3,5,5,5-heptamethyl-3-[(trimethylsilyl)oxy]trisiloxane | 241-867-7 | 17928-28-8 | Reproductive toxicity (pre-natal developmental toxicity) || Note: testing proposed with decamethyltetrasiloxane (EC no. 205-491-7, CAS no. 141-62-8) | 12/12/2014 | 26/01/2015 | Details | |
1,1,1,3,5,5,5-heptamethyl-3-octyltrisiloxane | 241-881-3 | 17955-88-3 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
17/06/2020 17/06/2020 |
03/08/2020 03/08/2020 |
Details | |
1,1,1,3,5,5,5-heptamethyltrisiloxane | 217-496-1 | 1873-88-7 |
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with Octamethyltrisiloxane, CAS 107-51-7 and 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7 Sub-chronic toxicity (90 day): inhalation
Note: testing proposed with 1,1,3,3-tetramethyldisiloxane, CAS 3277-26-7. |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
1,1,3,3-tetramethyl-1,3-divinyldisiloxane | 220-099-6 | 2627-95-4 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
25/06/2015 25/06/2015 |
10/08/2015 10/08/2015 |
Details | |
1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate | 244-894-2 | 22288-43-3 | Genetic toxicity in vivo | 10/05/2022 | 27/06/2022 | Details | |
1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate | 244-894-2 | 22288-43-3 | Reproductive toxicity (pre-natal developmental toxicity) | 03/03/2014 | 17/04/2014 | Details | |
1,1,3,3-tetramethylbutyl hydroperoxide | 227-369-2 | 5809-08-5 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
15/07/2014 15/07/2014 |
29/08/2014 29/08/2014 |
Details | |
1,1,3,3-tetramethylbutyl peroxyneodecanoate | 257-077-0 | 51240-95-0 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: Testing proposal is based on concern identified by the registrant | 01/09/2017 | 16/10/2017 | Details | |
1,1,3,3-tetramethylbutyl peroxyneodecanoate | 257-077-0 | 51240-95-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
02/06/2014 02/06/2014 |
17/07/2014 17/07/2014 |
Details | |
1,1,3,3-tetramethyldisiloxane | 221-906-4 | 3277-26-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90 day): inhalation |
29/04/2016 29/04/2016 |
13/06/2016 13/06/2016 |
Details | |
1,1,4,4-tetramethylbutane-1,4-diyl bis(2-ethylperoxyhexanoate) | 235-935-5 | 13052-09-0 | Long-term toxicity to fish || Note: Testing on fish needs to be considered in relation to the testing proposal for long-term toxicity to aquatic invertebrates | 12/12/2014 | 26/01/2015 | Details | |
1,10-decanediyl diacrylate | 235-922-4 | 13048-34-5 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity)||Note: testing proposed with Esterification products of acrylic acid with reaction products of 2,2-dimethylpropane-1,3-diol and methyloxirane (EC no. 701-440-2) Sub-chronic toxicity (90-day): oral||Note: testing proposed with Esterification products of acrylic acid with reaction products of 2,2-dimethylpropane-1,3-diol and methyloxirane (EC no. 701-440-2) |
06/06/2023 06/06/2023 06/06/2023 |
21/07/2023 21/07/2023 21/07/2023 |
Details | |
1,1`-(1,1-dimethyl-3-methylene-1,3-propanediyl)bisbenzene | 228-846-8 | 6362-80-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
1,2,3,4-tetrahydronaphthalene | 204-340-2 | 119-64-2 | Reproductive toxicity (extended one-generation reproductive toxicity study) | 26/03/2018 | 11/05/2018 | Details | |
1,2,3,4-tetrahydronaphthalene | 204-340-2 | 119-64-2 | Reproductive toxicity (two-generation reproductive toxicity) | 16/06/2011 | 01/08/2011 | Details | |
1,2,3,5,6,7-hexahydro-1,1,2,3,3-pentamethyl-4H-inden-4-one | 251-649-3 | 33704-61-9 | Reproductive toxicity (pre-natal developmental toxicity) | 30/06/2023 | 14/08/2023 | Details | |
1,2,3,6-tetrahydromethyl-3,6-methanophthalic anhydride | 246-644-8 | 25134-21-8 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
03/11/2023 03/11/2023 |
18/12/2023 18/12/2023 |
Details | |
1,2,4,5,7,8-Hexoxonane, 3,6,9-trimethyl-, 3,6,9-tris(Ethyl and Propyl) derivatives | - | - | Sub-chronic toxicity (90-day): oral | 30/06/2016 | 15/08/2016 | Details | |
1,2,4-Benzenetricarboxylic acid, mixed decyl and octyl triesters | 290-754-9 | 90218-76-1 | Sub-chronic toxicity (90-day): oral | 29/07/2011 | 12/09/2011 | Details | |
1,2,4-trimethylbenzene | 202-436-9 | 95-63-6 | Reproductive toxicity (pre-natal developmental toxicity) | 03/10/2023 | 17/11/2023 | Details | |
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters | 271-082-5 | 68515-40-2 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
16/06/2011 16/06/2011 |
01/08/2011 01/08/2011 |
Details | |
1,2-Benzenedicarboxylic acid, benzyl C7-9-branched and linear alkyl esters | 701-339-3 | - | Reproductive toxicity (pre-natal developmental toxicity) | 25/05/2020 | 09/07/2020 | Details | |
1,2-diacetoxybut-3-ene | 421-720-5 | 18085-02-4 | Sub-chronic toxicity (90-day): oral | 25/11/2021 | 10/01/2022 | Details | |
1,2-dihydroxybenzene,pyrocatechol | 204-427-5 | 120-80-9 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) |
15/04/2011 15/04/2011 |
30/05/2011 30/05/2011 |
Details | |
1,2-dimethylimidazole | 217-101-2 | 1739-84-0 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
19/10/2020 19/10/2020 |
03/12/2020 03/12/2020 |
Details | |
1,2-dimethylimidazole | 217-101-2 | 1739-84-0 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Reproductive toxicity (pre-natal developmental toxicity) |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
1,2-Ethanediamine, N-(2-aminoethyl)-, reaction products with glycidyl tolyl ether | 282-199-6 | 84144-79-6 | Reproductive toxicity (pre-natal developmental toxicity) || Note: Testing proposal is based on concern identified by the registrant. | 18/03/2021 | 03/05/2021 | Details | |
1,3,2-dioxathiolane 2,2-dioxide | 600-809-4 | 1072-53-3 | Genetic toxicity in vivo || Note: Link to registration dossier not given as the dossier not yet disseminated || Note: Testing proposal is based on concern identified by the registrant. | 24/01/2019 | 11/03/2019 | Details | |
1,3,3-trimethyl-N-(2-methylpropylidene)-5-[(2-methylpropylidene)amino]cyclohexanemethylamine | 259-393-4 | 54914-37-3 | Long-term toxicity to fish | 03/10/2023 | 17/11/2023 | Details | |
1,3,5-triallyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | 213-834-7 | 1025-15-6 | Reproductive toxicity (pre-natal developmental toxicity) | 25/09/2012 | 12/11/2012 | Details | |
1,3,5-triazine-2,4,6(1H,3H,5H)-trithione, trisodium salt | 241-749-5 | 17766-26-6 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
14/08/2014 14/08/2014 |
28/09/2014 28/09/2014 |
Details | |
1,3,5-tris(2,3-dibromopropyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | 257-913-4 | 52434-90-9 |
Long-term toxicity to fish Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/04/2023 03/04/2023 03/04/2023 |
22/05/2023 22/05/2023 22/05/2023 |
Details | |
1,3,5-Tris(oxiran-2-ylmethyl)-1,3,5-triazinane-2,4,6-trione (TGIC) | 219-514-3 | 2451-62-9 | Reproductive toxicity (two-generation reproductive toxicity) | 19/11/2010 | 03/01/2011 | Details | |
1,3,5-tris[3-(trimethoxysilyl)propyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | 247-465-8 | 26115-70-8 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
03/10/2023 03/10/2023 |
17/11/2023 17/11/2023 |
Details | |
1,3,5-tris[[4-tert-butyl-3-hydroxy-2,6-xylyl]methyl]-1,3,5-triazine-2,4,6(1H,3H,5H)-trione | 254-996-9 | 40601-76-1 | Reproductive toxicity (pre-natal developmental toxicity) with Rat | 24/07/2019 | 09/09/2019 | Details | |
1,3- and 1,4-cyclohexandicarboxyaldehyde | 482-020-3 | - | Reproductive toxicity (pre-natal developmental toxicity) | 15/07/2014 | 29/08/2014 | Details | |
1,3-Benzenediamine, coupled with diazotized m-phenylenediamine, acetates | 282-617-7 | 84281-74-3 | Genetic toxicity in vivo | 25/11/2021 | 10/01/2022 | Details | |
1,3-Benzenedimethanamine, N-(2-phenylethyl) derivs. | 445-790-1 | - | Sub-chronic toxicity (90 day): inhalation | 04/04/2014 | 19/05/2014 | Details | |
1,3-bis(isocyanatomethyl)benzene | 222-852-4 | 3634-83-1 | 6.1.2 Long-term toxicity to fish | 08/03/2024 | 22/04/2024 | Details | |
1,3-Butanediol, reaction products with 1,1'-methylenebis[4-isocyanatobenzene], propylene glycol and tripropylene glycol | 941-496-7 | 1689576-89-3 | Reproductive toxicity (extended one-generation reproductive toxicity study) || Note: testing proposed with 4,4'-methylenediphenyl diisocyanate (EC 202-966-0) | 01/04/2022 | 16/05/2022 | Details | |
1,3-diethyldiphenylurea | 201-645-2 | 85-98-3 | Sub-chronic toxicity (90-day): oral | 03/03/2014 | 17/04/2014 | Details | |
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione | 258-904-8 | 53988-10-6 |
Reproductive toxicity (pre-natal developmental toxicity)
Note: testing proposed with 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt (CAS: 61617-00-3) Reproductive toxicity (two-generation reproductive toxicity)
Note: testing proposed with 1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt (CAS: 61617-00-3) |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
1,3-dihydro-4(or 5)-methyl-2H-benzimidazole-2-thione, zinc salt | 262-872-0 | 61617-00-3 |
Reproductive toxicity (pre-natal developmental toxicity) Reproductive toxicity (two-generation reproductive toxicity) |
15/04/2014 15/04/2014 |
30/05/2014 30/05/2014 |
Details | |
1,3-diisopropylbenzene | 202-773-1 | 99-62-7 |
Reproductive toxicity (pre-natal developmental toxicity) Sub-chronic toxicity (90-day): oral |
18/02/2014 18/02/2014 |
04/04/2014 04/04/2014 |
Details | |
1,3-dimethylimidazolidin-2-one | 201-304-8 | 80-73-9 |
Reproductive toxicity (extended one-generation reproductive toxicity study) Sub-chronic toxicity (90-day): oral |
10/05/2022 10/05/2022 |
27/06/2022 27/06/2022 |
Details | |
1,3-dimethylimidazolidin-2-one | 201-304-8 | 80-73-9 | Reproductive toxicity (two-generation reproductive toxicity) | 15/04/2014 | 30/05/2014 | Details | |