(2R,3S,4S,5R)-3-(3,4-difluoro-2-methoxyphenyl) -4,5-dimethyl-5-(trifluoromethyl) tetrahydrofuran-2-carboxylic acid: (R )-alfa- methylbenzylamine salt (1:1)

Guidance on Safe Use

Handling and storage

Precautions for safe handling

Follow recommendations for handling potent pharmaceutical agents (i.e., use of engineering controls and/or other personal protective equipment if needed – See Section 8). Do not breathe mist/vapours/spray. Wash thoroughly after handling.

Conditions for safe storage, including any incompatibilities

Store at room temperature (~15°C to 30°C), protected from light, and away from incompatible materials. Avoid extreme temperatures

Transport information

Shipping

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Marine transport (UN RTDG/IMDG)

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Exposure controls / personal protection

Eye/face protection

Wear safety glasses with side shields, chemical splash goggles, or full-face shield, if necessary. Base the choice of protection on the job activity and potential for contact with eyes or face. An emergency eye wash station should be available.

Hand protection

Wear nitrile or other impervious gloves if skin contact is possible. Double gloves should be considered.

Skin and body protection

Wear appropriate gloves, lab coat, or other protective overgarment if skin contact is likely. Base the choice of skin protection on the job activity, potential for skin contact and solvents and reagents in use.

Respiratory protection

Choice of respiratory protection should be appropriate to the task and the level of existing engineering controls. For routine handling tasks, an approved and properly worn powered air-purifying respirator equipped with HEPA filters or combination filters should provide ancillary protection based on the known or foreseeable limitations of existing engineering controls. Use a positive- pressure air-supplied respirator if there is any potential for an uncontrolled release, when exposure levels are not known, or in any other circumstances where air purifying respirators may not provide adequate protection.

Environmental/ Exposure Controls

Avoid release to the environment and operate within closed systems wherever practicable. Air and liquid emissions should be directed to appropriate pollution control devices. In case of spill, do not release to drains. Implement appropriate and effective emergency response procedures to prevent release or spread of contamination and to prevent inadvertent contact by personnel.

Other protective measures

Wash hands in the event of contact with this material, especially before eating, drinking or smoking. Protective equipment is not to be worn outside the work area (e.g., in common areas or out-of-doors).