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EC number: 943-495-7 | CAS number: 689-65-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14-03-2016 to 19-03-2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study performed under GLP. All relevant validity criteria were met.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- inspected June 2013; signature: February 2016
- Type of method:
- flask method
- Water solubility:
- 14.8 mg/L
- Temp.:
- 20 °C
- pH:
- 5.6
- Remarks on result:
- other: Mean of 24, 48 and 72 h: deviation between replicates was: 10%
- Conclusions:
- Interpretation of results: slightly soluble (0.1-100 mg/L)
The test substance water solubility was determined to be 14.8 mg/L of solution at pH 5.6 and 20.0 °C. - Executive summary:
The water solubility of the substance was determined according to the flask method: OECD Method 105 and EU Method A.6 in accordance with GLP. Determinations preincubation with stirring rate of 300 rpm at 30 ± 0.5 °C, then 24 hours equilibration with a stirring rate of 100 rpm for at 20 ± 0.5 °C prior to sampling. The analytical method (UPLC MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The mean water solubility of the substance was determined to be 14.8 mg/L of solution at pH 5.6 and 20.0 °C.
Reference
Preliminary test
The determined solubility in double distilled water was in the range of 11.4 – 24.1 mg/L. For the application dose for the definitive study, 0.1 % (v/v) was used to facilitate the application procedure.
Definitive test:
The solubility of the test item in double distilled water was determined employing the flask method slow stirring approach at 20 ± 0.5 °C with preincubation at 30 ± 0.5 °C. The water solubility was respectively at pH 5.6:
Table 1.0. Water Solubility Results
Preincubation time |
Replicate No. |
Test item Concentration 1) |
|
Mean |
|||
24 h |
1 |
13.6 |
14.3 |
2 |
14.9 |
||
48 h |
1 |
13.8 |
15.8 |
2 |
17.7 |
||
72 h |
1 |
13.3 |
14.5 |
2 |
15.7 |
||
Mean (24 - 72 h) |
|
|
14.8 |
Deviation [%] (24 - 72 h) 2) |
10 |
1) Mean value of double injections, dilution factor of 400 and exact weights taken into account
2) Calculated according to formula 1
Formula 1:
Deviation (%) = 100 x (maximum value - minimum value) / minimum value
Temperatures were kept constant within ± 0.5 °C. The determined solubilities for each preincubation time did not differ by more than 15 %. The analytical method (UPLC MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.
Description of key information
Water Solubility: 14.8 mg/L at pH 5.6 and 20 °C, OECD TG 105, 2016
Key value for chemical safety assessment
- Water solubility:
- 14.8 mg/L
- at the temperature of:
- 20 °C
Additional information
Key study : EU Method A.6, 2016 : The water solubility of the substance was determined according to the flask method: OECD Method 105 and EU Method A.6 in accordance with GLP. Determinations preincubation with stirring rate of 300 rpm at 30 ± 0.5 °C, then 24 hours equilibration with a stirring rate of 100 rpm for at 20 ± 0.5 °C prior to sampling. The analytical method (UPLC MS, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The mean water solubility of the substance was determined to be 14.8 mg/L of solution at pH 5.6 and 20.0 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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