6,8-Dioxabicyclo[3.2.1]octan-4-one, (1S,5R)-

Melting point / freezing point

Link to relevant study record(s)

Reference

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

09 Apr - 21 Jun 2014

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 102 (Melting point / Melting Range)

Version / remarks:

27 July 1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Version / remarks:

30 May 2008

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

The Department of Health of the Government of the United Kingdom

Type of method:

capillary method

Remarks:

melting temperature devices with liquid bath

Key result

Melting / freezing pt.:

< -20 °C

Atm. press.:

1 013 hPa

Remarks on result:

other: Atmospheric pressure not reported, experiment assumed to be done at ambient conditions.

Key result

Melting / freezing pt.:

< 253 K

Atm. press.:

1 013 hPa

Remarks on result:

other: Atmospheric pressure not reported, experiment assumed to be done at ambient conditions.

Cooling data for Determinations 1 and 2 are shown in Table 1 and Table 2 below. The graphs of temperature (K) versus time (s) for Determinations 1 and 2 are attached.

Table 1: Determination 1

Time [s]	Temperature [K]	Time [s]	Temperature [K]	Time [s]	Temperature [K]
0	293.7	540	272.2	1080	259.7
30	291.7	570	270.7	1110	259.2
60	291.2	600	269.7	1140	258.7
90	290.7	630	268.7	1170	258.2
120	290.2	660	267.7	1200	257.7
150	289.7	690	267.2	1230	257.2
180	289.2	720	266.2	1260	256.7
210	288.2	750	265.7	1290	256.2
240	286.2	780	265.2	1320	255.7
270	283.2	810	264.7	1350	255.7
300	281.2	840	264.2	1380	255.2
330	280.2	870	263.2	1410	254.7
360	279.7	900	262.7	1440	254.2
390	277.2	930	262.2	1470	253.7
420	276.2	960	262.2	1500	253.2
450	274.7	990	261.2	1530	252.7
480	273.7	1020	260.7	1560	252.2
510	273.2	1050	260.2	-	-

Observation: No change in test item during testing

Result: Freezing temperature <-20°C (<253 K)

Table 2: Determination 2

Time [s]	Temperature [K]	Time [s]	Temperature [K]	Time [s]	Temperature [K]
0	294.7	510	272.2	1020	258.2
30	293.7	540	270.7	1050	257.7
60	291.7	570	270.2	1080	257.2
90	290.2	600	269.2	1110	256.7
120	288.7	630	268.7	1140	256.2
150	287.2	660	268.2	1170	255.7
180	285.7	690	266.7	1200	255.2
210	283.2	720	265.7	1230	254.7
240	281.7	750	265.2	1260	254.2
270	281.2	780	264.7	1290	254.2
300	280.7	810	263.7	1320	253.7
330	279.2	840	262.7	1350	253.2
360	278.2	870	261.7	1380	253.2
390	276.2	900	260.7	1410	252.7
420	275.2	930	259.7	1440	252.7
450	274.2	960	258.7	1470	252.7
480	273.2	990	258.7	1500	252.2

Observation: No change in test item during testing

Result: Freezing temperature <-20°C (<253 K)

Neither of the samples froze under the conditions of the test

Conclusions:

A freezing temperature of <-20°C (<253 K) at 1013 hPa was determined for the substance using a relevant test method and in compliance with GLP. The result is considered to be reliable.

Description of key information

Freezing temperature <-20°C (<253 K) (OECD 102)

Key value for chemical safety assessment

Melting / freezing point at 101 325 Pa:

-20 °C

Additional information

A freezing temperature value of <-20°C (<253 K) at 1013 hPa was determined for the submission substance using a capillary method (melting temperature device with liquid bath) in accordance with OECD Test Guideline 102 and in compliance with GLP. The result is considered to be reliable.