2-Propenoic acid, 2-chloro-, 3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl ester

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

17 Jun - 5 Sep 2013

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study with acceptable restrictions

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

yes

Remarks:

: To obtain a more accurate value for water solubility, it was decided to perform an additional test based on the flask method in which evaporation was excluded as much as possible.

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

yes

Remarks:

: To obtain a more accurate value for water solubility, it was decided to perform an additional test based on the flask method in which evaporation was excluded as much as possible.

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Deviations:

yes

Remarks:

: To obtain a more accurate value for water solubility, it was decided to perform an additional test based on the flask method in which evaporation was excluded as much as possible.

Principles of method if other than guideline:

Deviation from the protocol: As the maximum difference (MD) in the water solubility test according to column elution method was >30% between the two flow rates (12 mL/h and 24 mL/h), the test substance was most likely volatile. To obtain a more accurate value for water solubility, it was decided to perform an additional test based on the flask method in which evaporation was excluded as much as possible.

GLP compliance:

yes (incl. QA statement)

Remarks:

Ministerie van Volksgezondheid, Welzijn en Sport, Den Haag

Type of method:

column elution method

Remarks:

additionally: flask method

Key result

Water solubility:

< 0.6 mg/L

Temp.:

20 °C

pH:

7.3 - 8.4

Preliminary test:

The content of test substance dissolved in the water sample was after two centrifugation steps 0.0076 mg/L and after three centrifugation steps 0.00148 mg/L.

Main column elution test:

Flow rate [mL/h]	Sample no.	Concentration analysed			pH
		Individual [mg/L]	Mean [mg/L]	CV [%]
24-I	1	0.496	0.564	8.2	8.4
	2	0.582
	3	0.7922
	4	1.0002
	5	1.1342
	6	0.547
	7	0.539
	8	0.546
	9	0.598
	10	0.638
12	1	0.009	0.009	51	8.0
	2	0.007
	3	0.006
	4	0.005
	5	0.008
	6	0.012
	7	0.017
	8	0.017
	9	0.007
	10	0.004
24-II	1	0.037	0.034	13	7.3
	2	0.034
	3	0.029
	4	0.032
	5	0.028
	6	0.031
	7	0.036
	8	0.040
	9	0.029
	10	0.039

The turbidity of the eluates was < 0.2 NTU. According to this, no undissolved particles were detected in the eluates. No test substance was detected in the samples from the blank column.

A large variability was observed in the water solubility results obtained by the column elution test (0.6, 0.009 and 0.03 mg/L). To obtain a more accurate value for water solubility, it was decided to perform an additional test based on the flask method.

Additional test (flask method):

Stirring time [h]	Analysed concentration [mg/L]	Mean [mg/L]	pH
3	0.383	0.278	7.9
6	0.201
24	0.250
29	0.279

Based on all results, an accurate value could not be obtained. Water solubility was estimated to be < 0.6 mg/L.

Exact temperatures: 19.7 ± 0.3 °C (column elution); 19.8 ± 0.3 °C (flask method).

Description of key information

< 0.6 mg/L at 20 °C

Key value for chemical safety assessment

Water solubility:

0.6 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the substance was measured using column elution method according to EU method A.6 and guidelines OECD 105 and OPPTS 830.7840, with the following restriction: since the substance was difficult to test, and the results were inconsistent, the additional test using flask method was performed. The final result summarizes the two approaches.