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Diss Factsheets
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EC number: 700-834-1 | CAS number: 9041-08-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
There were several reports in basic toxicokinetics, weight of evidence. In these studies, there was no evidence indicated that the substance has bioaccumulation potential.
Key value for chemical safety assessment
Additional information
Absorption and Distribution
IV infusion of heparin results in an immediate anticoagulant response. However, the response may be delayed by 1-2 hr following SC administration due to variation in bioavailability by this route. Lowmolecular-weight heparins are absorbed more uniformly than unfractionated heparin. The compound is not widely distributed into body tissues, though it does appear to be stored in or on the surface of vascular endothelium, mast cells, and macrophages both systemically and in the lung. Animal studies have shown that the ratio of heparin bound to the vascular endothelium to heparin in the bloodstream is roughly 100:1 (BENDSTRUP, 1998).
Heparin is well deposited when administered by inhalation. However, it is rapidly stored in the lungs, with only a small fraction being distributed systemically. High inhalation doses are therefore required to produce significant effects on coagulation. When given by this route, peak systemic levels are achieved about 1 hr after administration, with maximum anticoagulant activity occurring 6-8 hr post-dosing. By contrast, localized anti-inflammatory effects following a single dose of inhaled heparin may persist for up to 24 hr (BENDSTRUP, 1998).
The plasma elimination half life of heparin increases with dose, from one to five hr over the range of 100-800 IU/kg. Low-molecular-weight preparations have longer half lives than standard preparations. After inhalation, clearance occurs slowly. The elimination half life from lung tissue is slightly less than 24 hr (BENDSTRUP, 1998).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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