Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 635-476-4 | CAS number: 88349-88-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Cloquintocet acid is of low acute oral, inhalation and dermal toxicity. The acute oral LD50 in the rat is >2000 mg/kg bw. The acute 4-hour inhalation LC50 in the rat is >6.11 mg/L. The acute dermal LD50 in the rat is >5000 mg/kg bw.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- Klimisch score = 1. Modern study compliant with current test guidelines and GLP
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 6 110 mg/m³
- Quality of whole database:
- Klimisch score = 1. Modern study compliant with current test guidelines and GLP
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- Klimisch score = 1. Modern study compliant with current test guidelines and GLP
Additional information
The acute oral toxicity of cloquintocet acid was determined according to OECD test guideline 423 (Verma, 2013d).
Two sets of fasted Wistar rats (3 females/set) were given a single oral dose of test substance in 0.5% (w/v) carboxy methyl cellulose (CMC) in distilled water at a dose of 2000 mg/kg bw and were observed for 14 days. There were no treatment-related mortality, clinical signs or changes in body weight recorded. Necropsy findings of the terminally sacrificed rats did not reveal any abnormality of pathological significance. The acute oral LD50 was found to be greater than 2000 mg/kg bw.
Acute Inhalation Toxicity:
The acute inhalation toxicity of cloquintocet acid was determined according to OECD test guideline 403 (Verma, 2013e).
A group of 5 male and 5 female Wistar rats were exposed to a time-weighted average (TWA) concentration of 6.11 mg cloquintocet acid/L air (limit test) using a nose-only inhalation exposure system. The rats were exposed for 4 hours followed by a 14-day post-exposure observation period. The mass median aerodynamic diameter (MMAD) of aerosolized test substance was determined to be 2.37 μm with an average geometric standard deviation (GSD) of 2.42. There was no treatment-related mortality, no clinical signs of toxicity, no effects on body weight changes, and no abnormalities observed at necropsy. The 4 hour acute inhalation LC50 was found to be greater than of 6.11 mg/L.
Acute Dermal Toxicity:
The acute dermal toxicity of cloquintocet acid was determined according to OECD test guideline 402 (Verma, 2013f).
A group of Wistar rats (5 males and 5 females) were dermally exposed to the test substance for 24 hours following application at a limit dose of 5000 mg/kg body weight. The required quantity (1111.5 to 1457.5 mg) of test item (moistened with 0.2 mL distilled water) was applied over the clipped area (approximately 7 × 5 cm body surface area) and the rats were observed for a period of 14 days. There were no treatment-related mortality, clinical signs, changes in body weight or necropsy findings recorded. The acute dermal LD50 was found to be greater than 5000 mg/kg bw.
Justification for classification or non-classification
Cloquintocet acid is of low acute oral toxicity (LD50 >2000 mg/kg bw), low acute inhalation toxicity (4 -h LC50 > 6.11 mg/L) and low acute dermal toxicity (LD50 >5000 mg/kg bw). Cloquintocet acid does not meet the criteria for classification for acute toxicity according to the CLP Regulation 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.