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EC number: 634-598-5 | CAS number: 106565-71-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- April 2013 - Nov 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study has been performed according to OECD and/or EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- Principles of method if other than guideline:
- The abiotic sterile control was prepared with deionised water and not with medium.
This procedure, according to standard operating procedures, is chosen to reduce
the possibility of any microbial activity. It was wrongly indicated in the study plan. - GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (3S,5R,8aS)-3-cyclohexyl-hexahydro-2H-[1,3]oxazolo[3,2-a]pyridine-5-carbonitrile
- EC Number:
- 634-598-5
- Cas Number:
- 106565-71-3
- Molecular formula:
- C14H16N2O1
- IUPAC Name:
- (3S,5R,8aS)-3-cyclohexyl-hexahydro-2H-[1,3]oxazolo[3,2-a]pyridine-5-carbonitrile
- Test material form:
- solid: crystalline
- Details on test material:
Identification PAM-Oxazolopiperidine
Chemical name (3S,5R,8aS)-(+)Hexahydro-3-phenyl-5H-
oxazolo[3,2a]pyridine-5-carbonitrile
Batch no BS12010625
CAS no. 106565-71-3
Molecular formula C14H16N2O
BMG sample no. M1302-00843-01
Physical form Solid
Purity 99.7% (w/w)
Theoretical oxygen demand 2.803 mg O2/mg (calculated according to chapter
5.2 assuming nitrification)
Test substance storage At room temperature, protected from light
Stability Stable under storage conditions
Expiry date 8 November 2013
additional analytical information is provided in section 1.4
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Duration of test (contact time):
- ca. 28 d
Initial test substance concentration
- Initial conc.:
- ca. 100 mg/L
- Based on:
- ThOD/L
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
Results and discussion
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- ca. 23
- Sampling time:
- 28 d
- Details on results:
- Based on the data of the individual O2 determinations, the mean
biodegradability in the Manometric Respirometry Test of PAM-Oxazolopiperidine
was calculated to be 23% after 28 days as compared to the theoretical oxygen
demand (ThOD).
BOD5 / COD results
- Results with reference substance:
- The procedure control sodium benzoate reached 80% biodegradation after 14 days,
thus confirming suitability of inoculum and test conditions.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- PAM-Oxazolopiperidine is not biodegradable in the Manometric Respirometry Test.
- Executive summary:
The biodegradability of PAM-Oxazolopiperidine exposed to microorganisms derived from activated sludge of a municipal sewage treatment plant was investigated under aerobic static exposure conditions. (Manometric Respirometry Test, OECD 301F)
A biodegradability of 23% of PAM-Oxazolopiperidine based on O2 consumption was observed during 28 days as compared to the theoretical oxygen demand (ThOD).
The procedure control sodium benzoate reached 80% biodegradation after 14 days, thus confirming suitability of inoculum and test conditions.
The calculated biodegradation based on DOC measurements reached 48% for PAM-Oxazolopiperidine and 99% for sodium benzoate, respectively. The data show that the consumed O2 was used for partial mineralization of the test compound, since the determined degradation values based on BOD were lower as compared to those based on DOC.
PAM-Oxazolopiperidine did not reach the pass level of 60% for ready biodegradability in the Manometric Respirometry Test within the 10-d window as well as after 28 days and, therefore, cannot be termed as readily biodegradable.
PAM-Oxazolopiperidine is not biodegradable in the Manometric Respirometry Test.
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