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Diss Factsheets
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EC number: 609-066-0 | CAS number: 35123-06-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish early-life stage toxicity
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE: ECOSAR v2.2
2. MODEL: Estimation of Toxicity to Aquatic Organisms Using ECOSAR v2.2: Chemical Class: Amides: Fish Chronic value (ChV)
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL: CC(C(=O)N(C)C)O
4. SCIENTIFIC VALIDITY OF THE MODEL: see attached documents
5. APPLICABILITY DOMAIN: see attached documents - Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Software tool(s) used including version: ECOSAR v2.2
- Model(s) used: Estimation of Toxicity to Aquatic Organisms Using ECOSAR v2.2: Chemical Class: Amides: Fish Chronic Value
- Model description: see field 'Justification for non-standard information', 'Attached justification' and/or 'Cross-reference' - GLP compliance:
- no
- Remarks:
- predicted data
- Analytical monitoring:
- not required
- Details on sampling:
- not applicable
- Vehicle:
- no
- Test organisms (species):
- other: Different freshwater fish species
- Test type:
- other: QSAR prediction
- Water media type:
- freshwater
- Key result
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Remarks:
- proxy derived by dividing ChV by √2.
- Effect conc.:
- 16.4 mg/L
- Remarks on result:
- other: A proxy to derive the NOEC is to divide the ChV by √2 (ECHA Practical guide on How to use and report (Q)SARs, version 3.1, 2016).
- Duration:
- 30 d
- Dose descriptor:
- other: ChV (chronic value)
- Effect conc.:
- 23.2 mg/L
- Remarks on result:
- ChV (chronic value, QSAR)
- Remarks:
- The chronic value (ChV) is defined as the geometric mean of the no observed effect concentration (NOEC) and the lowest observed effect concentration (LOEC) (ECHA Practical guide on How to use and report (Q)SARs, version 3.1, 2016).
- Conclusions:
- The ECOSAR QSAR model (v2.2) predicted a chronic toxicity value (freshwater fish) of 23.2 mg/L. The derived NOEC is considered to be 16.4 mg/L, indicating no long-term toxicity for freshwater fish.
- Executive summary:
A Chronic toxicity value (ChV) for freshwater fish was calculated by using the software ECOSAR v2.2 (model "Estimation of Toxicity to Aquatic Organisms Using ECOSAR v2.2: Chemical Class: Amides: Fish Chronic value (ChV)"). The ChV is defined as the geometric mean of the no observed effect concentration (NOEC) and the lowest observed effect concentration (LOEC) and was predicted to be 23.2 mg/L. The NOEC, which can be derived by dividing the ChV by √2, was determined to be 16.4 mg/L.
Reference
The ChV is defined as the geometric mean of the no observed effect concentration (NOEC) and the lowest observed effect concentration (LOEC) and was predicted to be 23.2 mg/L. The NOEC, which can be derived by dividing the ChV by √2, was determined to be 16.4 mg/L.
Description of key information
A Chronic toxicity value (ChV) for freshwater fish was calculated by using the software ECOSAR v2.2 (model "Estimation of Toxicity to Aquatic Organisms Using ECOSAR v2.2: Chemical Class: Amides: Fish Chronic value (ChV)"). The ChV, which is defined as the geometric mean of the no observed effect concentration (NOEC) and the lowest observed effect concentration (LOEC), was predicted to be 23.2 mg/L. The NOEC, which can be derived by dividing the ChV by √2, was determined to be 16.4 mg/L.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- NOEC
- Effect concentration:
- 16.4 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.