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EC number: 926-605-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key read across studies of C-6 normal and iso paraffins (hexanes) and naphthenes (methyl-cyclohexane, dimethylcyclohexane), 25-35% n-hexane (Hine et al., 1970; Klimisch score=2) were identified to support each acute toxicity endpoint (oral, dermal, and inhalation) for this substance.
Acute Toxicity-Oral LD50>16750 mg/kg in rats (OECD TG 401)
Acute Toxicity-Dermal LD50>3350 mg/kg in rabbits (OECD TG 402)
Acute Toxicity-Inhalation LC50>259354 mg/m3 in rats (OECD TG 403)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 16 750 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 259 354 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 3 350 mg/kg bw
Additional information
In a key read-across acute oral toxicity study of C-6 normal and iso paraffins (hexanes) and naphthenes (methyl-cyclohexane, dimethylcyclohexane), 25-35% n-hexane (Hine et al., 1970; Klimisch score=2), 6 male rats were administered doses up to 25 ml/kg of commercial n-hexane by oral gavage, and observed for 14 days post-dosing. No mortality was observed at any of the doses. The oral LD50 is therefore > 25 ml/kg (16750 mg/kg; density of 0.67) which makes the test substance not classified under EU criteria.
In a key read-across acute inhalation toxicity study (Hine et al., 1970; Klimisch score=2), groups of 10 male rats were exposed to concentrations of
C-6 normal and iso paraffins (hexanes) and naphthenes (methyl-cyclohexane, dimethylcyclohexane), 25-35% n-hexane
for 4 hours. Animals were then observed for clinical signs and mortality for at least 6 days post-exposure. Several animals died during the exposure period. Surviving animals experienced severe toxicological effects during the exposure. One animal experienced convulsions during and after exposure and died on day 6 post-exposure. The LC50 was determined to be 73,680 ppm (259354 mg/m3), and the test substance is therefore not classified under EU criteria.
In a key read-across acute dermal toxicity study of C-6 normal and iso paraffins (hexanes) and naphthenes (methyl-cyclohexane, dimethylcyclohexane), 25-35% n-hexa
ne (Hine et al., 1970; Klimisch score=2), 5.0 ml/kg was placed on the shaved skin of 3 male rabbits. The test area was then covered with a saran wrap sleeve for 4 hrs. After the exposure period, the test substance washed off, and the animals observed for toxicity and mortality over the next 14 days. No animals died; however, they did show signs of discomfort and uncoordination after the exposure. The LD50 for dermal exposure is > 5.0 ml/kg (3350 mg/kg). Therefore, the test substance is not classified under EU criteria.Justification for classification or non-classification
The substance is not classified as acutely toxic under EU criteria. It is classified as a Category 1 aspiration hazard.
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