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EC number: 927-957-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From August 10, 2017 to August 22, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- Batch No.: WD0066442; Purity: 100 % (UVCB); Appearance: amber liquid; Homogeneity: homogeneous
- Key result
- Water solubility:
- > 25.3 - < 88.3 mg/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 1 002 mg/L
- Incubation duration:
- 7 d
- Temp.:
- 20 °C
- pH:
- >= 4.12 - <= 4.86
- Details on results:
- As solubility was dependent on nominal concentration, no exact value for the solubility of the test substance in water can be stated. The solubility range for the tested nominal concentration 100 – 1002 mg/L is 25.3 – 88.3 mg/L at 20.0 ± 0.5 °C, corresponding to 25 – 9 % of the test substance relating to the nominal concentration of the test substance.
- Conclusions:
- Under the study conditions, at the plateau, the concentration of the test substance in water lay in the range of 25.3 – 88.3 mg/L at 20.0 ± 0.2 °C for the following nominal load range of the test substance in water: 100 – 1002 mg/L. Therefore, 25 – 9 % of the test substance was dissolved in water relating to the nominal concentration of the test substance. As the DOC method measures the sum of all dissolved parts of the test substance, this study does not provide any insights on the stability of the test substance in aqueous medium.
- Executive summary:
A study was conducted to determine the solubility of the test substance according to OECD Guideline 105 and EU Method A.6, in compliance with GLP. The solubility of the test substance in water was determined by measurement of DOC concentration in the filtrated test solutions using TOC analyser. Based on the results of the pre-test, the flask method was selected for the main study. In the main test, six different loading rates of the test substance were chosen to study the effect of the loading rate on the measured water solubility: 100, 300, 500, 602, 801 and 1002 mg/L. Three flasks 1A - C with the same loading rate (500 mg/L) were used during equilibration. Seven vessels (flasks blank, 1C (for the sampling point 72 h) and 2 – 6) were set onto the shaking apparatus immediately. After 24 ± 2 hours, flask 1B (for the sampling point 48 h) and after 48 ± 2 hours, flask 1A (for the sampling point 24 h) were set on the shaker and all flasks were shaken for further 24 ± 2 hours at room temperature (20.0 ± 0.5 °C). Then, flasks 1A - 1C were taken from the shaker, samples were taken, membrane filtered and analysed for DOC via TOC analyser. Because of a difference of more than 15 % between the concentrations on days 2 and 3 the test was prolonged and the flasks 1A – 1C were further measured to get the values on days 4 – 7. Due to a difference of less than 15 % between the concentrations on days 6 and 7 and no upward tendency, the test was finished on day 7. Therefore, on day 7, vessels 2 – 6 were sampled and analysed for TOC in the same fashion. No Tyndall effect could be observed indicating that no colloidal dispersed particles or micells are present. Under the study conditions, at the plateau, the concentration of the test substance in water lay in the range of 25.3 – 88.3 mg/L at 20.0 ± 0.2 °C for the following nominal load range of the test substance in water: 100 – 1002 mg/L. Therefore, 25 – 9 % of the test substance was dissolved in water relating to the nominal concentration of the test substance. As the DOC method measures the sum of all dissolved parts of the test substance, this study does not provide any insights on the stability of the test substance in aqueous medium (Affolter, 2017).
Reference
Dependency of solubility on amount of the test substance (nominal load) was perceived in the main test, too:
Flask |
Measured Conc. test sub. [mg/L] |
Nominal Conc. test sub. [mg/L] |
Dissolved Part [%] |
pH value |
2 |
25.3 |
100.0 |
25 |
4.86 |
3 |
51.5 |
300.0 |
17 |
4.44 |
1* |
59.6 |
500.3 |
12 |
-** |
4 |
78.2 |
602.0 |
13 |
4.28 |
5 |
76.8 |
801.0 |
10 |
4.21 |
6 |
88.3 |
1002.0 |
9 |
4.12 |
*mean value of flasks 1A – 1C (days 4 – 7)
**value was not measured via pH meter
Description of key information
The water solubility was determined according to OECD Guideline 105 and EU Method A.6 (Affolter, 2017).
Key value for chemical safety assessment
- at the temperature of:
- 20 °C
Additional information
25.3 – 88.3 mg/L
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