1-(1,3-benzodioxol-5-yl)-4,4-dimethyl-1-penten-3-one

Toxicity to aquatic algae and cyanobacteria

Administrative data

Endpoint:

toxicity to aquatic algae and cyanobacteria

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2018

Report date:

2018

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 201 (Freshwater Alga and Cyanobacteria, Growth Inhibition Test)

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

(1E)-1-(2H-1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-one

EC Number:

604-446-2

Cas Number:

144850-45-3

Molecular formula:

C14H16O3

IUPAC Name:

(1E)-1-(2H-1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-one

Test material form:

solid: particulate/powder

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

yes

Remarks:

ultrapure water

Details on test solutions:

a special solubilization protocol was carried out before the experimentation according to OECD n°23 guidance document on aquatic toxicity testing of difficult subtances and mixtures

Test organisms

Test organisms (species):

Raphidocelis subcapitata (previous names: Pseudokirchneriella subcapitata, Selenastrum capricornutum)

Study design

Test type:

semi-static

Water media type:

not specified

Limit test:

no

Total exposure duration:

72 h

Test conditions

Test temperature:

range of 21 to 24°C

Nominal and measured concentrations:

test concentration : control - 0.3 - 1 - 3.2 - 10 - 32 and 100 mg/L

Details on test conditions:

control : 6 biotioc replicates
each concentration : 3 replicates

Reference substance (positive control):

yes

Remarks:

potassium dichromate

Results and discussion

Effect concentrations

Effect concentrations 1

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

4.86 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

growth rate

Effect concentrations 2

Key result

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

> 0.3 - < 1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: yield inhibition

Details on results:

The validity criteria were successfully fulfilled.

Results with reference substance (positive control):

not specified

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

The results obtained for Stiripentol Stade 1 are :
- EC50-72h = 4.86 mg/L based on growth rate
- EC50-72h = 0.3 to 1 mg/L based on yield inhibition
In regard to these results the test item can be classified in Category : Acute II.

Executive summary:

The acute toxicity on aquatic algae was performed according the OECD 201 guideline.

The results obtained for Stiripentol Stade 1 are :

- EC50-72h = 4.86 mg/L based on growth rate

- EC50-72h = 0.3 to 1 mg/L based on yield inhibition

In regard to these results the test item can be classified in Category : Acute II.