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Diss Factsheets
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EC number: 618-855-9 | CAS number: 925430-39-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Three different charges of Benzenemethanol, alpha-(chloromethyl)-3 -hydroxy-, (alphaR)- were tested for their mutagenic potential in OECD 471 guideline studies (in compliance with GLP), based on the ability to induce point mutation in selected loci of several bacterial strains, i.e. Salmonella typhimurium (TA 1535, TA 100, TA 1537, TA98) and Escherichia coli (WP2 uvrA) in a reverse mutation assay (BASF 2014). Bacteria were exposed to 3.3 - 5 200 µg of charges of high purity per plate in a standard plate test in the presence and absence of a metabolizing system (rat liver S-9 mix). No precipitation of the test substance or bacteriotoxic effects were found with and without S9 mix. An increase in the number of his+ revertants was observed without S9 mix or after the addition of a metabolizing system. It was therefore concluded that the test substance is mutagenic under these experimental conditions.
The third test was conducted with a charge of low purity. There were no relevant increases in his+ or trp+ revertants with or without the addiion of S9 mix. No precipitation of the test substance with and without S9 mix were observed but bacteriotoxic effects depending on the strain and test conditions from about 500 μg/plate onward.
Based on the results of the studies conducted with the charges of high purity it was finally concluded that the test substance is mutagenic under these experimental conditions.
Justification for selection of genetic toxicity endpoint
Three genetic toxicity in vitro studies are available. This study is adequate for covering this endpoint.
Short description of key information:
Benzenemethanol, alpha-(chloromethyl)-3-hydroxy-, (alphaR)- is considered to be mutagenic in the bacterial reverse mutation study (OECD 471, GLP).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Benzenemethanol, alpha-(chloromethyl)-3 -hydroxy-, (alphaR)- was mutagenic in the Ames test. No further data on genetic toxicity is available. Based on this classification for genetic toxicity is not possible in accordance with EU Directive 67/548 (DSD) and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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