1H-Imidazole-1-propanenitrile

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: GLP guideline study without anayltical monitoring

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1998

Report date:

1998

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: German industrial standard test guideline DIN 38412, part 11

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Imidazole-1-propionitrile(8CI);1-(2-Cyanoethyl)imidazole

EC Number:

607-301-1

Cas Number:

23996-53-4

Molecular formula:

C6H7N3

IUPAC Name:

Imidazole-1-propionitrile(8CI);1-(2-Cyanoethyl)imidazole

Details on test material:

- Name of test material (as cited in study report): Cyanethylimidazol
- Analytical purity: >95%

Sampling and analysis

Analytical monitoring:

yes

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Details on test organisms:

TEST ORGANISM
- Common name: water flea
- Strain: STRAUS
- Source: The clone of Daphnia magna STRAUS used was supplied by Institut National de Recherche Chimique Appliquée, France, in 1978 . The daphnids are cultured under standard conditions in the laboratory .
- Age at study initiation (mean and range, SD): 2 - 24 hours

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test conditions

Test temperature:

19.7-21.3°C

pH:

7.9-8.0

Dissolved oxygen:

8.3 - 8.5 mg/l

Nominal and measured concentrations:

Nominal test concentrations (mg/L): 12.5, 25, 50 and 100

Details on test conditions:

TEST SYSTEM
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4

Reference substance (positive control):

yes

Remarks:

potassium dichromate

Results and discussion

Effect concentrations

Effect concentrations 1

Duration:

48 h

Dose descriptor:

EC0

Effect conc.:

>= 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: Nominal concentration verified analytically

Effect concentrations 2

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: Nominal concentration verified analytically 95% CL

Effect concentrations 3

Duration:

48 h

Dose descriptor:

EC100

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: Nominal concentration verified analytically

Any other information on results incl. tables

	Cumulative immobility after x hours (%)
Nominal concentration (mg/l)	3 h	6 h	24 h	48 h
Control
Conc1
Conc2
Conc3
Conc4
Conc5
Conc6
Conc7
Conc8
Conc9

Applicant's summary and conclusion

Executive summary:

Administrative data: add

- Purpose flag if key study

- "used for MSDS" if key study

- data: Study period if possible, otherwise delete entry

Data source:

- add year

- add date

- add company study number or report number if stated

- Check performing laboratory

Test material: add

- CAS #

- Name of test material (as cited in study report)

- Analytical purity, physical state?

Vehicle: yes/no?

Test conditions: check

- Test temperature

- pH

- Dissolved oxygen

- nominal and measured concentrations

- Details on test conditions

- No of vessels per concentration

- No of vessels per control

Results and discussion: add

- Effect concentrations

Any other information on results incl. tables:

- fill in table, replace ConcX with the real test concentrations