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EC number: 922-551-4 | CAS number: 1187440-66-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- October 2008
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
PHYSICO-CHEMICAL PROPERTIES
- Melting point: 70-75°C
- Boiling point: >300°C
- Vapour pressure: 6.66 x 10-5 Pa.
- Water solubility (under test conditions): <1mg/L
OTHER PROPERTIES (if relevant for this endpoint)
- Results of test for ready biodegradability: not considered as ready biodegradable - Analytical monitoring:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name:Daphnia magna
- Age at study initiation (mean and range, SD):24 Hours
- Length at study initiation (length definition, mean, range and SD): between 560µm to 800µm
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- CaCO3: 250 mg/L
- Test temperature:
- 20+-1°C
- pH:
- 7.9
- Dissolved oxygen:
- 8.2 to 8.5
- Salinity:
- CaCl2 H2O=297mg/L
MgCl26H2O=167 mg/L
NaHCO3=200mg/L
K2SO4=26mg/L - Nominal and measured concentrations:
- 1; 10; 100 mg/L
- Details on test conditions:
- TEST SYSTEM
- Renewal rate of test solution (frequency/flow rate):every 24 hours
- No. of organisms per vessel:5
- No. of vessels per concentration (replicates):4
- No. of vessels per control (replicates):4
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10 - Reference substance (positive control):
- yes
- Remarks:
- potassium dichromate
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Details on results:
- no sign of stress was observed on the daphnids after the 48 hours of exposition
- Results with reference substance (positive control):
- the last toxic response obtained on the reference item potassium dichromate (6th October 2008) gives an EC50-24 hours of 1.09 mg/L, indicating that the daphnids sensitivity is correct (within the accepted interval of 0.6-2.1 mg/L fixed by the international standard ISO 6341 may 1996) and in accordance with the historical data obtained by the laboratory.
- Reported statistics and error estimates:
- none
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50-48 hours of the test item on Cladocera micro crustacean Daphia magna is superior to the highest tested concentration, i.e 100mg/L, value expressed in nominal concentration.
- Executive summary:
The acute immobilisation screening test of the micro crustacean Daphnia magna was performed on the test item "LCE07105". The results obtained on the toxicological endpoint "immobilisation" gives an EC50 -48 hours superiot to the highest tested concentration, i. e 100mg/L.
This result espressed in mg/L of the nominal concentration shows that no toxicity was observed in the concentrations selected in this test on the micro crustacean Daphnia magna. No sign of stress was observed on the Daphnids during 48 hours of the experiment.
In order to control and to confirm the test item solubilisation and its stability throughout the study, an analysis of the test solution contained in the aquarium was performed at the 100mg/L test item concentration and in the filtered control: Total phosphorus was chosen as tracer and was analyzed at the start and the end of the study (as the test was performed with semi static condition, the final sample was aged of 24 hours instead of 48 hours).
Results are presented as follow:
Nominal test Item concentrations in mg/L totol [P] at 0h at 48h Filtered control <LOD <LOD 100 0.049 mg/L 0.056mg/L
Reference
The acute immobilisation screening test of the micro crustacean Daphnia magna was performed on the test item "LCE07105". The results obtained on the toxicological endpoint "immobilisation" gives an EC50 -48 hours superiot to the highest tested concentration, i. e 100mg/L.
This result espressed in mg/L of the nominal concentration shows that no toxicity was observed in the concentrations selected in this test on the micro crustacean Daphnia magna. No sign of stress was observed on the Daphnids during 48 hours of the experiment.
In order to control and to confirm the test item solubilisation and its stability throughout the study, an analysis of the test solution contained in the aquarium was performed at the 100mg/L test item concentration and in the filtered control: Total phosphorus was chosen as tracer and was analyzed at the start and the end of the study (as the test was performed with semi static condition, the final sample was aged of 24 hours instead of 48 hours).
Results are presented as follow:
Nominal test Item concentrations in mg/L |
totol [P] |
|
|
at 0h |
at 48h |
Filtered control |
|
|
100 |
0.049 mg/L |
0.056mg/L |
Description of key information
The acute immobilisation screening test of the micro crustacean Daphnia magna was performed on the registered substance. The results obtained on the toxicological endpoint "immobilisation" gives an EC50 -48 hours superiot to the highest tested concentration, i. e 100mg/L.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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