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EC number: 473-690-8 | CAS number: 738602-93-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Nov 2004 - Mar 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-A (Determination of the "Ready" Biodegradability - Dissolved Organic Carbon (DOC) Die-Away Test)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 473-690-8
- EC Name:
- -
- Cas Number:
- 738602-93-2
- Molecular formula:
- not applicable for UVCB
- IUPAC Name:
- (2R,3R,4S,5S,6R)-2-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; (2S,3R,5R)-4-{[(2R,3R,4R,5S,6R)-5-{[(2R,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}hexane-1,2,3,5,6-pentol
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source (i.e. manufacturer or supplier) and lot/batch number of test material: Sponsor, Batch 4G08
- Purity, including information on contaminants, isomers, etc.: 54.2 % Maltotriosyl glucoside
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: at room temperature at about 20 °C away from direct sunlight
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure):
The study was performed with aerobic activated sludge from a wastewater treatment plant (ARA Ergolz II, Füllinsdorf, Switzerland) treating predominantly domestic wastewater.
- Laboratory culture: no laboratory culture
- Method of cultivation: no cultivation
- Storage conditions: no storage
- Storage length: no storage
- Preparation of inoculum for exposure:
The sludge was washed tice with tap water by centrifugation and the superantant liquid phase was decanted. A homogenized aliquot of the final sludge suspension was weighed, thereafter dried and the ratio of wet to dry weight was calculated.
- Pretreatment: washing
- Concentration of sludge: 4 g dry mass per litter
- Initial cell/biomass concentration: no determination of biomass
- Water filtered: no
- Type and size of filter used, if any: - Duration of test (contact time):
- 14 d
Initial test substance concentration
- Initial conc.:
- 75.2 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Composition of medium: according to guidelines
- Additional substrate: non
- Solubilising agent (type and concentration if used): none
- Test temperature: 23 °C
- pH: 7.4
- pH adjusted: yes, at start of test only
- CEC (meq/100 g): not applicable
- Aeration of dilution water: no
- Suspended solids concentration: not determined
- Continuous darkness: yes
- Other:
TEST SYSTEM
- Culturing apparatus: no culturing apparatus used
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: no special method used
- Method used to create anaerobic conditions: no special method used
- Measuring equipment: TOC Analyzer equipped with an autosampler
- Test performed in closed vessels due to significant volatility of test substance: no
- Test performed in open system: yes, loosely covered flasks
- Details of trap for CO2 and volatile organics if used: not used
- Other:
SAMPLING
- Sampling frequency: on day 0, 3, 7, 10 and 14
- Sampling method: 10 ml of sample were taken
- Sterility check if applicable: not stated
- Sample storage before analysis: no
- Other:
CONTROL AND BLANK SYSTEM
- Inoculum blank: yes
- Abiotic sterile control: yes
- Toxicity control: yes
- Other:
STATISTICAL METHODS: none applied
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
- Test performance:
- no unusual observations reported
% Degradation
- Key result
- Parameter:
- % degradation (DOC removal)
- Value:
- 94
- Sampling time:
- 14 d
- Details on results:
- In the test flasks, containing the test item and activated sludge (inoculum), the mean concentration of DOC (dissolved organic carbon) rapidly decreased from initially 30.1 mg/L on Day 9 to 1.9 mg/L on Day 3.
In the abiotic control, containing the test item and poisoned medium, the DOC concentration varied from 33.3 to 31.8 mg/L over the exposure period of 14 days and were not significantly different from the initial DOC concentration of 33.2 mg/L measured on Day 0. Thus no significant abiotic elimination occured under the test conditions.
The reference item was completely biodegraded within the first three days of exposure, thus confirming suitability of the activated sludge.
In the toxicity control, containing the test item, the reference item and activated sludge, the initial DOC concentraiton of 59.4 mg/L measured on Day 0 decreased to 2.1 mg/L on Day 14. Biodegradation amounted to 97 % within 14 days of exposure. Thus, according to the test guidelines, it is assumed that the test item is not inhibitory to activated sludge at the test concentration of 75 mg/L because degradation was clearly >35 % within 14 days.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- MG-60 is readily biodegradable under the test conditions.
- Executive summary:
The test item MG-60 was investigated for its ready biodegradability in a 28 Day DOC Die-Away test" according to EU C.4-A and OECD 301 A. In accordance with the testing guidelines, the test was ended ahead of schedule after 14 days of exposure, because the biodegradation curves of the test and reference item had reached a plateau for three determinations.
In the test flasks, containing the test item MG-60 and activated sludge (inoculum), the mean concentrations of dissolved organic carbon (DOC) rapidly decreased by 94 % of the initial values within the first three days of the test period. Therefore, MG-60 was found to be highly biodegradable under the test conditions, an dthe pass level for ready biodegradability, i.e. 70 % DOC removal in a 10-day window within a 28-day test period, was reached. Consequently, the test item MG-60 is readily biodegradable under the test conditions.
In the abiotic control, containing the test item and poisoned mineral medium, no significant elimination was noted after 14 days of exposure (based on DOC measurements).
The reference item sodium benzoate was completely biodegraded within the first three days of exposure, thus confirming suitability of the activated sludge.
In the toxicity control, containing the test item, hte reference item sodium benzoate and activated sludge (inoculum), the initial DOC decreased by 97 % within 14 days of exposure. According to the test guidelines, it is assumed that the test item is not inhibitory to activated sludge at the tested concentration of 75 mg/L, because degradation was > 35 % within 14 days.
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