SCH.58235-A

Guidance on Safe Use

First-aid measures

Emergency measure - Inhalation: Remove from exposure. If breathing ceases, give artificial

respiration. Get medical attention immediately.

Emergency measure - Eyes: Rinse opened eye for 15 minutes under running water or with

normal saline solution. Get medical attention immediately.

Emergency measure - Skin: If irritation occcurs seek medical attention.

Emergency measure - Ingestion: In case of accidental swallowing, give large amounts of

water and seek medical attention immediately.

Fire-fighting measures

Recommended extinguishing agent: Water, dry chemical or CO2.

Product arising from burning: The substance is combustible and will burn if involved in a

fire, evolving noxious fumes (eg carbon oxides and fluorine

derivatives).

Product determined by test: N

Protective equipment: Full protective clothing and self-contained breathing

apparatus must be worn.

Fight the fire from a safe distance or protected location.

Accidental release measures

Emergency measures in case of spillage: Evacuate personnel from immediate vicinity.

Wear appropriate personal protective equipment conforming to

the relevant national or international standards, as

mentioned in section 2.3.10.

Avoid dust formation. Absorb spillages of solutions with a

suitable inert material (eg. sand or soil). Carefully

transfer the spillage to waste containers, or use a sealed

industrial vacuum machine. Containers filled with waste

material must be labelled in the same way as the original

substance containers.

Clean the spillage area by dissolving in solvent if

necessary and do not discharge to drain.

Dispose of waste material in accordance with local

regulations and/or according to Schering Plough Good

Environmental Practice (GEP). Incineration is the preferred

disposal method.

Handling and storage

Handling: The substance should be stored, handled and used under

conditions of good industrial hygiene and in conformity with

any local regulations in order to avoid exposure.

Engineering controls are necessary to reduce exposure to the

substance.

When exposure cannot be prevented or adequately controlled

appropriate personal protective equipment should be worn.

Such protective equipment should conform to the appropriate

international or national standards as follows;

Chemical protective gloves to Standard EN374

Chemical protective clothing to Standard EN368

Eye protection to Standard EN166.

Furthermore, when respiratory protective equipment has to be

used, it must be capable of adequately controlling exposure,

be suitable for the purpose, and conform to the appropriate

international or national standards, such as a dust mask

conforming to EN149 FFP1.

These measures should be regarded as a minimum.

Storage: Store in a cool, dry, well ventilated area.

Keep containers tightly closed when not in use.

Packaging of the substance and or preparation: Double polythene lined fibreboard drums or plastic kegs.

Transport information

Shipping

SpecialProvisions

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

Shipping

Special provisions / remarks

Remarks:

Transport code: None
Transport: Avoid crushing the containers. In the event of a spillage,
observe the warning labels on the container.

SpecialProvisions

Stability and reactivity

Danger other than fire: None Known.

Chemical reaction with water: None which is hazardous.

Dust explosion: The dust explosion constant, Kst, is 286 bar m/s (20 L

sphere) MIE < 10mg.

Under normal conditions of use, this material does not

present a significant explosion hazard.

Dust explosion determined by test: Y

Disposal considerations

Industry - Possibility of recovery/recycling: There will be no discharge to the environment. Recovery from

minor spillages or accidental discharge is not economically

or technically feasible, and such waste material will be

disposed of by incineration. In principle, it may be

possible to recover larger spillages of uncontaminated

material for subsequent use.

Industry - Possibility of neutralisation: The notification tests have shown concern for mutagenicity

in an Ames and Mouse Lymphoma Assay test, however, this has

been mitigated by a negative in-vivo micronucleus test. The

substance is acutely toxic to aquatic organisms and

dangerous to the environment.

No chemical treatment is practicable to neutralise these

hazardous properties.

The dust hazard will be minimised by appropriate handling

and storage.

Industry - Possibility of destruction: controlled discharge: Contaminated containers or spillages of solutions mixed with

inert material (eg. sand or soil) should not normally  be

disposed of by landfill.

Industry - Possibility of destruction - incineration: The substance can be disposed of by incineration by burning

under controlled conditions at a licensed waste treatment

processor in accordance with local regulations. Stack gases

should be scrubbed, because noxious fumes (eg. carbon oxides

and fluorine derivatives) could be formed.

Industry - Possibility of destruction - water purification: The substance should not normally be discharged directly to

the sewage system or the aqueous environment. However,

adverse effects  on sewage treatment systems would be

unlikely.

Industry - Possibility of destruction - other: None.

Public at large - Possibility of recovery/recycling: Not applicable.

Public at large - Possibility of neutralisation: Not applicable.

Public at large - Possibility of destruction: controlled discharge: Not applicable

Public at large - Possibility of destruction - incineration: Not applicable.

Public at large - Possibility of destruction - water purification: Not applicable.

Public at large - Possibility of destruction - others: Not applicable.