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EC number: 296-117-1 | CAS number: 92257-28-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Hydrolysis:
According to annex VIII column 2 the study does not need to be conducted because the test substance is highly insoluble in water.
Biodegradation in water:
Biodegradation study was performed of the structurally and functionally similar read across chemicals. The studies are as mentioned below:
Study 1. Biodegradation study was conducted for evaluating the percentage biodegradability of read across test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 0.2% by BOD and 0.3 % by GC parameter in 14 days. Thus, based on percentage degradation test chemical is considered to be not readily biodegradable in water.
Study 2. Similar study was conducted on structurally and functionally similar read across chemical. Biodegradation study was conducted for evaluating the percentage biodegradability of test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 0 % by BOD and 0 % by HPLC parameter in 28 days. Thus, based on percentage degradation of test chemical is considered to be not readily biodegradable in water.
Thus based on both studies for structurally and functionally similar read across chemicals it can be concluded that the test chemical N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen -2-amine (92257-28 -8) was not readily biodegradable in water.
Adsorption:
Estimation Programs Interface was used to predict the soil adsorption coefficient i.e Koc value of test chemical N-(2-ethylhexyl)-1- [4-(2-phenyldiazen-1-yl)phenyl]naphthalen-2-amine (CAS No. 92257 -28 -8). The soil adsorption coefficient i.e Koc value of N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl) phenyl]naphthalen-2-amine was estimated to be 6600000 L/kg (log Koc= 6.819) by means of MCI method (at 25 deg C). This Koc value indicates that the substance N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen-2-amine has a very strong sorption to soil and sediment and therefore have negligible migration potential to ground water.
Additional information
Hydrolysis:
According to annex VIII column 2 the study does not need to be conducted because the test substance is highly insoluble in water.
Biodegradation in water:
Various experimental data for the target compound N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen-2-amine (CAS No. 92257-28-8) and supporting weight of evidence studies for its
structurally and functionally similar closest read across substance were reviewed for the biodegradation end point which are summarized as below:
Study 1.
Biodegradation study was conducted for evaluating the percentage biodegradability of read across test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 0.2% by BOD and 0.3 % by GC parameter in 14 days. Thus, based on percentage degradation test chemical is considered to be not readily biodegradable in water.
Study 2.
Similarly study was conducted on structurally and functionally similar read across chemical. Biodegradation study was conducted for evaluating the percentage biodegradability of test substance. Concentration of inoculum i.e, sludge used was 30 mg/l and initial test substance conc. used in the study was 100 mg/l, respectively. The percentage degradation of test substance was determined to 0 % by BOD and 0 % by HPLC parameter in 28 days. Thus, based on percentage degradation of test chemical is considered to be not readily biodegradable in water.
On the basis of above results for target chemical N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen-2-amine (CAS No. 92257-28-8) and for its read across substance from authoritative database, it can be concluded that the test substance N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl] naphthalen-2-amine (CAS No. 92257-28-8) can be expected to be not readily biodegradable in nature.
Adsorption:
Various predicted and experimental data for the target compound N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen-2-amine (CAS No. 92257-28-8) and supporting weight of evidence studies for its closest read across substance with logKow as the primary descriptor were reviewed for the adsorption end point which are summarized as below:
In the first weight of evidence Estimation Programs Interface was used to predict the soil adsorption coefficient i.e Koc value of test chemical N-(2-ethylhexyl)-1- [4-(2-phenyldiazen-1-yl)phenyl] naphthalen-2-amine (CAS No. 92257 -28 -8). The soil adsorption coefficient i.e Koc value of N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl) phenyl]naphthalen-2-amine was estimated to be 6600000 L/kg (log Koc= 6.819) by means of MCI method (at 25 deg C). This Koc value indicates that the substance N-(2-ethylhexyl)-1-[4-(2-phenyldiazen-1-yl)phenyl]naphthalen-2-amine has a very strong sorption to soil and sediment and therefore have negligible migration potential to ground water.
First predicted data was supported by the second supporting study for the structurally and functionally similar read across chemical from authoritative database. The Koc value for chemical was estimated by using a structure estimation method based on molecular connectivity indices. The estimated Koc value was 130000 dimensionless and log Koc is 5.11 this log Koc value suggests that test chemical has a very strong sorption to soil and sediment and therefore have negligible migration potential to ground water.
Similarly another read across chemical from authoritative database 2017 was also used as it supports the behavior of chemical. Adsorption study was conducted for estimating the adsorption coefficient (Koc) value of test chemical. The adsorption coefficient (Koc) value was calculated using a structure estimation method based on molecular connectivity indices. The adsorption coefficient (Koc) value of test substance was estimated to be 4800000 (Log Koc = 6.681). This Koc value indicates that the substance has a very strong sorption to soil and sediment and therefore have negligible migration potential to ground water.
Thus based on the overall adsorption result it is concluded that the test substance have very strong sorption to soil and sediment and therefore have negligible migration potential to ground water.
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