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Diss Factsheets
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EC number: 294-785-9 | CAS number: 91770-03-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10-01-2012 to 23-04-22012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- GLP compliance:
- yes
- Type of method:
- flask method
- Water solubility:
- < 4.93 mg/L
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not determined
- Conclusions:
- The water solubility of the substance is less than 4.93 mg/L at 20 °C.
- Executive summary:
Test Guidance
OECD Guideline No. 105 and EC Method A6: Flask method
Method and materials
The test was performed with reduced shaking and equilibration periods as it is known that the functional groups within the test item structure are known to be hydrolytically unstable. Although the test item itself may not be prone to rapid hydrolysis as it is highly hydrophobic, individual molecules of the test item that dissolve may be. The broad peak in the chromatography at approximately 2 minutes was not used in the calculations or considered as a main component of the test item. The main components of the test item were, as expected highly retained and required a gradient to 100% tetrahydrofuran to elute them.
Results
The liquid test item very easily dispersed in water to give a stable suspension, even though it was only shaken at a relatively slow 50 rpm which could not be cleaned up by centrifugation. The water solubility samples were therefore filtered in an attempt to remove the excess test item and although they appeared clear, excess test item may still have remained. Therefore, it was decided to take the result as a limit value. Although the sample blank was subtracted, which showed a peak at the same time, the peak in the samples may have contained background extracts additional to those also in the sample blank. The final result was considered to be higher than the actual water solubility of the test item, especially when compared with the calculated value.
Conclusions
The water solubility of the substance is less than 4.93 mg/L at 20°C.
Reference
The concentration of test item in the sample solutions is shown in the following table:
Sample Number |
Time shaken at ca. 30°C (hours) |
Time equilibrated at 20°C (hours) |
Concentration (g/L) |
1 |
1 |
0.5 |
<4.93E-03 |
2 |
2 |
0.5 |
<4.88E-03 |
3 |
3 |
0.5 |
<3.24E-03 |
Description of key information
The water solubility of the substance is less than 4.93 mg/L at 20 °C (OECD 105 and EU Method A.6).
Key value for chemical safety assessment
- Water solubility:
- 4.93 mg/L
- at the temperature of:
- 20 °C
Additional information
The key study was performed in accordance with OECD Guideline No. 105 and EU Method A.6: Flask method. The test was performed with reduced shaking and equilibration periods as it is known that the functional groups within the test item structure are known to be hydrolytically unstable. The main components of the test item absorbed strongly to the HLPC column. The liquid test item very easily dispersed in water to give a stable suspension, even though it was only shaken at a relatively slow 50 rpm which could not be cleaned up by centrifugation or filtration. Therefore, it was decided to take the result as a limit value. Furthermore, samples may have contained background extracts additional to those also in the sample blank. The final result was considered to be higher than the actual water solubility of the test item. The water solubility of the substance is less than 4.93 mg/L at 20 °C.
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