Registration Dossier
Registration Dossier
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EC number: 264-980-3 | CAS number: 64628-44-0
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- This study was conducted to OECD guidelines
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- not specified
- Dissociating properties:
- not determined
- No.:
- #1
- Remarks on result:
- not determinable
- Remarks:
- Direct titration in pure water is not possible due to low solubility (solubility 0.025 mg/L).
- Conclusions:
- Due to poor water solubility (=0.04 mg/L), it was not possible to specify a pK value. Triflumuron exhibited no basic properties in aqueous solution.
Reference
Titration with hydrochloric acid in water containing 50% 2-propanol as solubilizing agent:
Contrary to the OECD guidelines, titration was carried out in the presence of a solubilizing agent to improve solubility. Despite the content of 50% 2-propanol, 0.2 g of triflumuron did not dissolve in 50 ml of water-propanol mixture, so titration had to be carried out in a suspension.
The titration curve which was obtained showed no potential jump.
(Aminotriazole, which was measured as reference substance, produced a pK value of 4.20 under the same measurement conditions).
Titration with perchloric acid in glacial acetic acid:
In order to clarify the question of whether triflumuron has any basic properties at all, titration was carried out in glacial acetic acid, which is not specified in the OECD guidelines.
The titration curve which was obtained showed no potential jump.
(Aminotriazole, which was measured as reference substance, produced a pK value of -0.05 under the same measurement conditions).
Description of key information
Due to poor water solubility (≤0.04 mg/L), it was not possible to specify a pK value.
Key value for chemical safety assessment
Additional information
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