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EC number: 263-502-0 | CAS number: 62314-22-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The oral LD50 of Solvent-free Dabco TMR is greater than 2000 mg/kg of body weight in rats (OECD 423)
A non-guideline study on the oral acute toxicity of 75% Hydroxypropyl, N-2-, N,N,N-trimethylammonium 2-ethylhexanoate solution in ethyleneglycol was tested with male albino rats of the Sherman-Wistar Strain. Study determined LD50=2.8 ml/kg b.w. (equivalent to 2800 mg/kg bw)
Hydroxypropyl, N-2-, N,N,N-trimethylammonium 2-ethylhexanoate 75% in Ethyleneglycol was tested for acute dermal toxicity on rabbits. The LD50 was > 2 000 mg/kg b.w.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
- Specific details on test material used for the study:
- Identity Solvent-free Dabco TMR Batch# meyersl.20160601
Test Article See Appendix A for Test Article Characterization.
Characterization
Supplied by Air Products and Chemicals, Inc.
Date Received 18Jul2016
Storage Room temperature and humidity
Description Clear light-yellow viscous liquid
Specific Gravity 1.04
Sample Preparation Used as received - Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Animals were received from Charles River, Raleigh NC, on 06 Sep 2016. Following an acclimation period of at least five days, healthy male and healthy, non-pregnant and nulliparous female Sprague Dawley rats were assigned to treatment groups without conscious bias.
The weight
variation of the animals used did not exceed ±20% of the mean body weight of the previously dosed animals within a sex. - Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- A single dose was administered orally by syringe and dosing needle.
- Doses:
- The test article was used as received and the dose was based on the sample weight as calculated from the specific gravity. A single dose was administered orally by syringe and dosing needle at a dose level of 2000 mg/kg to female rats and 2000 mg/kg male rats.
- No. of animals per sex per dose:
- 3 male and 3 female rats
- Control animals:
- no
- Details on study design:
- Animals were observed at 15 minutes, 1, 2 and 4 hours postdose and once daily for 14 days for toxicity and pharmacological effects and twice daily for mortality. Body weights were recorded immediately pretest, weekly, at death and at termination.
- Statistics:
- N/A
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed.
- Clinical signs:
- other: Not measured
- Gross pathology:
- Gross necropsy revealed no observalbale abnormalities.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- All three female and three male rats survived following the 2000 mg/kg oral dose.
No abnormal physical signs were observed among all six animals.
The animals gained body weight by study termination and the gross necropsy revealed no observable abnormalities.
The oral LD50 of Solvent-free Dabco TMR Batch# meyersl.20160601 is greater than 2000 mg/kg of body weight in rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- 2016 Guideline study
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Quality of whole database:
- Waiver on basis of substance corrosivity.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- One group of ten albino rabbits weighing between 2.5 and 3.5 kg each were employed in this study.
All animals had their backs clipped free of hair 24 hours prior to testing. One half of the animals had their backs abraded prior to dosing.
The sample was dosed as supplied. 2.0 g/kg dosage was administered.
All rabbits were weighed and the correct amunt of experimental material was applied to the back of each animal. These treated areas were covered with large gauze patches and an impervious material was wrapped snugly around the trunk of each animal.
The dressings were removed after twenty-four hours and any excess material was removed and the approximate amount remaining was noted. The animals were observed for a 14 day period for signs of toxicity and for mortalities. - GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- yes
- Species:
- rabbit
- Sex:
- not specified
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- All animals had their backs clipped free of hair 24 hours prior to testing. One half of the animals had their backs abraded prior to dosing.
The sample was dosed as supplied. 2.0 g/kg dosage was administered. - Duration of exposure:
- 24 h
- Doses:
- 2 g/kg b.w.
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- One group of ten albino rabbits weighing between 2.5 and 3.5 kg each were employed in this study.
All animals had their backs clipped free of hair 24 hours prior to testing. One half of the animals had their backs abraded prior to dosing.
The sample was dosed as supplied. 2.0 g/kg dosage was administered.
All rabbits were weighed and the correct amunt of experimental material was applied to the back of each animal. These treated areas were covered with large gauze patches and an impervious material was wrapped snugly around the trunk of each animal.
The dressings were removed after twenty-four hours and any excess material was removed and the approximate amount remaining was noted. The animals were observed for a 14 day period for signs of toxicity and for mortalities. - Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed
- Clinical signs:
- other: Not available
- Gross pathology:
- Not available
- Other findings:
- Not available
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Hydroxypropyl, N-2-, N,N,N-trimethylammonium 2-ethylhexanoate 75% in Ethyleneglycol was tested for acute dermal toxicity on rabbits. Test determined LD50 > 2 000 mg/kg b.w.
- Executive summary:
Hydroxypropyl, N-2-, N,N,N-trimethylammonium 2-ethylhexanoate 75% in Ethyleneglycol was tested for acute dermal toxicity on rabbits. Test determined LD50 > 2 000 mg/kg b.w.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- 1975 non-guideline study on product containing test substance.
Additional information
Justification for classification or non-classification
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