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EC number: 249-282-9 | CAS number: 28880-24-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Diisooctyl succinate
- EC Number:
- 249-282-9
- EC Name:
- Diisooctyl succinate
- Cas Number:
- 28880-24-2
- Molecular formula:
- C20H38O4
- IUPAC Name:
- bis(6-methylheptyl) succinate
- Test material form:
- liquid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- yes
- Remarks:
- Carboxymethyl Cellulose (at 30 mg/l concentration)
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Name of Species : Daphnia magna
No. of Daphnia group : 20 Daphnids per concentration (four replicates of single
Concentration and each containing Five Daphnids)
Temperature : 18 - 22°C
No. of Dose concentration : 5
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 21.2-21.6 °C
- pH:
- 6.0-7.2
- Dissolved oxygen:
- ≥ 4 mg/l content of the water
- Nominal and measured concentrations:
- A limit test was performed at a dose concentration of 100 mg/l of the test
item prior to the main study. On the basis of the findings main study was
conducted by preparing five concentrations of the test item (i.e. 2, 4, 8,
10, 20 mg/l). - Details on test conditions:
- Immobilization : In the control not more than 10 % of the Daphnia should immobilize during the test period.
Light conditions : 16 hours light and 8 hours dark cycle - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 9.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 95 % F. limit : 7.16- 11.77
- Details on results:
- EC50 : 9.30 mg/l of water
95 % F. limit : 7.16- 11.77
Lowest concentration causing 100 % immobility in Daphnia : 40 mg/ l of water - Reported statistics and error estimates:
- EC50 was calculated using Finney’s Probit Analysis
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of this study toxicity to Daphnia i.e.EC50 of “Dicapryl Succinate” came out as:
EC50 : 9.30 mg/l of water
95 % F. limit : 7.16- 11.77
The compound has been tested as per ‘OECD Guideline for the testing of Chemicals, Daphnia Acute Immobilization Test Guideline No. 202 adopted on 13th April 2004’ - Executive summary:
The study was conducted to determine the ‘Immobilization test of ‘Dicapryl Succinate’ on a benthic zooplankton strain ‘Daphnia magna’.
In the present study, a limit test was performed at 100 mg/l concentration, of the test item ‘Dicapryl Succinate’ with 20 Daphnia (four replicates of five Daphnids each). Based on the result of the limit test, the Main Test was conducted taking five different concentrations of the test item (20, 40, 60, 80 and 100 mg/l). Similarly 20 Daphnia (four replicates of five Daphnids each) for negative control (water) and solvent control (at 30mg/l concentration of CMC) groups were used (the volume of solvent, used in the test concentrations and control was kept same).
On the basis of these concentrations, the EC50 was estimated and the lowest concentration causing 100 % immobility, were determined, and which came out as:
EC50 : 9.30 mg/l of water
95 % F. limit : 7.16- 11.77
Lowest concentration causing 100 % immobility in Daphnia : 40 mg/ l of water
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