Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Workers - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
DNEL related information

Workers - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion

Workers - Hazard for the eyes

Local effects

Hazard assessment conclusion:
low hazard (no threshold derived)

Additional information - workers

The prediction indicates that the studied compound is identified as a potential mutagen causing chromosome-type aberrations.

Based on the observed results, the No Observed Adverse Effect Level (NOAEL) of test item 3-(isodecyloxy)propylammonium acetate is 50 mg/kg body weight/day when administered for a period of 28 consecutive days by oral (gavage) route to Sprague Dawley rats under the test conditions employed.

Based on the results, the No Observed Adverse Effect Level (NOAEL) of 3-(isopropyl) ammonium acetate was found to be 125 mg/kg body weight, the mid dose when administered to the males for two weeks pre-mating, during mating and up to the day before sacrfice during post-mating period (total of 39 days), to the females for two weeks pre-mating, during mating, pregnancy (gestation) an up to lactation day 13, under experimental conditions employed.

General Population - Hazard via inhalation route

Systemic effects

Long term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
DNEL related information
Explanation for the modification of the dose descriptor starting point:

Substance is classified as Skin Corr.1B, H314. According to Annex VII, Column B: The study/ies do(es) not generally need to be conducted it the substance is calssified as skin corrosion.

Local effects

Long term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
DNEL related information

General Population - Hazard via dermal route

Systemic effects

Long term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
DNEL related information

Local effects

Long term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion
Acute/short term exposure
Hazard assessment conclusion:
insufficient hazard data available (further information necessary)
Most sensitive endpoint:
skin irritation/corrosion

General Population - Hazard via oral route

Systemic effects

Long term exposure
Hazard assessment conclusion:
other toxicological threshold
Value:
50 mg/kg bw/day
Most sensitive endpoint:
repeated dose toxicity
Acute/short term exposure
Hazard assessment conclusion:
other toxicological threshold
Value:
125 mg/kg bw/day
Most sensitive endpoint:
developmental toxicity / teratogenicity
DNEL related information

General Population - Hazard for the eyes

Local effects

Hazard assessment conclusion:
low hazard (no threshold derived)

Additional information - General Population