2,2'-[azobis(1-methylethylidene)]bis[4,5-dihydro-1H-imidazole dihydrochloride

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

23 October 2015 - 03 December 2015

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Reason / purpose for cross-reference:

reference to other study

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test item is not stable in aqueous solution. Therefore the determination of the log Pow according to OECD 107 (shake flask method) and OECD 117 (HPLC method) is not feasible. The log Pow was estimated using the single solubilities in n-octanol and water.

GLP compliance:

yes (incl. QA statement)

Type of method:

estimation method (solubility ratio)

Partition coefficient type:

octanol-water

Analytical method:

titration method

Key result

Type:

Pow

Partition coefficient:

> 0 - < 0

Temp.:

23 °C

Remarks on result:

other: pH net determined

Details on results:

The test item is miscible with water at room temperature (T = 23 °C) and at T = 20 °C (± 0.5 °C) in a concentration range of >= 20 g/100 g and <= 30 g/100 g (BASF, GLP-study No. 15L00378 / study report under the endpint "water solubility").
Solubility of the test item in n-octanol is 77 mg/L ± 2 mg/L (BASF, GLP-study No. 15L00379)

Conclusions:

The partition coefficient of 2,2'-[Azobis (1-methylethylidene)] bis [4,5-dihydro-1H-imidazole] dihydrochloride is estimated at > -3.59 and < -3.41

Description of key information

The partition coefficient is estimated by determination of the ratio of the single solubility of the test item in n-octanol and water.

Key value for chemical safety assessment

Log Kow (Log Pow):

-3.5

at the temperature of:

20 °C