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EC number: 239-590-1 | CAS number: 15541-60-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
MPP is non-irritating to the skin but is an irritant to the eyes of rabbits.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 15 June 2004 to 14 April 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Huntingdon Life Sciences, Eye Research Centre, Eye, Suffolk, IP23 7PX, UK
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: reputable laboratory animal supplier
- Age at study initiation: 12-20 weeks
- Weight at study initiation: 2.0 to 3.5 kg
- Housing: suspended cages
- Diet: certified rabbit diet, ad libitum
- Water: mains drinking water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 to 23
- Humidity (%): 30 to 70
- Air changes (per hr): at least 15
- Photoperiod (hrs dark / hrs light): 12 light / 12 hours dark
IN-LIFE DATES: From: 1 March 2005 To: 4 March 2005 - Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.5g
- Concentration (if solution): moistened with 0.5ml water - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: on the back of each animal
- % coverage: not reported
- Type of wrap if used: elasticated corset
REMOVAL OF TEST SUBSTANCE
- Washing: residual material was removed by gentle swabbing with cotton wool soaked in distilled water
- Time after start of exposure: 4 hours
SCORING SYSTEM:
Erythema and Eschar formation: scale of 1-4 (1 = no erythema; 4 = severe erythema/eschar formation
Oedema formation: scale of 1-4 (1= no oedema; 4= severe oedema) - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No evidence of skin irritation was noted in the study.
Reference
Individual skin reactions
Skin Reaction |
Observation Time |
Individual Scores-Rabbit Number and Sex |
Total |
||
Male 1 |
Male 2 |
Male 3 |
|||
Erythema/Eschar |
1 Hour |
0 |
0 |
0 |
(0) |
24 Hours |
0 |
0 |
0 |
0 |
|
Formation |
48 Hours |
0 |
0 |
0 |
(0) |
72 Hours |
0 |
0 |
0 |
0 |
|
Oedema Formation |
1 Hour |
0 |
0 |
0 |
(0) |
24 Hours |
0 |
0 |
0 |
0 |
|
48 Hours |
0 |
0 |
0 |
(0) |
|
72 Hours |
0 |
0 |
0 |
0 |
|
Sum of 24 and 72-hour Readings (S) 0 |
|||||
Primary Irritation Index (S/6) 0/6 = 0.0 |
|||||
Classification NON-IRRITANT |
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 October 2010 to 7 January 2011
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.2400 (Acute Eye Irritation)
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Ministry of Agriculture, Forestry and Fisheries, Test Data for Registration of Agricultural Chemicals, Eye Irritation (2-1-5), 12 Nohsan No. 8147, Agricultural Production Bureau, November 24, 2000.
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: reputable laboratory animal supplier
- Age at study initiation: 31 or 34 weeks
- Weight at study initiation: 3.69 to 4.30 kg
- Housing: each animal was housed individually in a plastic cage with perforated floors
- Diet: standard laboratory rabbit diet, ad libitum
- Water: drinking water, ad libitum
- Acclimation period: 12 or 20 weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16 to 20
- Humidity (%): 40 to 0
- Air changes (per hr): continuous air supply
- Photoperiod (hrs dark / hrs light): 12 hours / 24 hour period
IN-LIFE DATES: From: 3 November 2010 To: 30 November 2010 - Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated left eye of each animal was used as a control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: 0.1 mL (approximately 92 mg) - Duration of treatment / exposure:
- Single exposure
- Observation period (in vivo):
- 15 days
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): none - test substance not removed
SCORING SYSTEM:
Ocular irritation: cornea opacity 0-4; area of cornea 0-4
Corneal ulceration: iris 0-2; conjunctivae redness 0-3; chemosis 0-4
Discharge: 0-4
TOOL USED TO ASSESS SCORE: ophthalmoscope or pencil beam torch - Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0.7
- Max. score:
- 1
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- opacity
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within:
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 15 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1.7
- Max. score:
- 2
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 15 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 2.3
- Max. score:
- 3
- Reversibility:
- fully reversible within: 8 days
- Interpretation of results:
- other: slightly irritating
- Remarks:
- Criteria used for interpretation of results: other: Kay and Calandra method (1962)
- Conclusions:
- The highest total mean score was 20.0 occurring at the 24 hour observation; accordingly under the criteria Kay and Calandra (1962) MPP was classified as “mildly irritating” to the eye.
At least 2 out of 3 animals showed a conjunctival redness score ≥2 and an oedema (chemosis) score ≥2 which was reversible within 21 days when. Calculated as the mean scores following grading at 24, 48 and 72 hours after instillation of the test material. MPP is therefore classified under CLP as Irritating to Eyes, Category 2.
Reference
A crimson-red conjunctival appearance was apparent in all animals throughout the first 48 hours after instillation persisting in two at the 72 hour examination; injection of the conjunctival blood vessels was apparent in all cases 24 hours later. Very slight to moderate chemosis was evident in all animals throughout the first 48 hours after instillation persisting in two at the 72 hour examination. Very slight to substantial discharge was also apparent during the first 72 hours after instillation.
Scattered or diffuse areas of opacity covering up to half the corneal surface were apparent in all animals 24 hours after instillation, persisting in one animal at the 48 hour examination and in the remaining animal at the 72 hour observation.
The treated eye of each animal was overtly normal 15 days after instillation.
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
In an acute dermal irritation study, the substance a single 4 -hour, semi-occluded application of the test material to the intact skin of three rabbits produced no evidence of skin irritation or corrosive effects.
In an eye irritation study, the substance was administered as a single ocular dose of a volume of 0.1 mL. A crimson-red conjunctival appearance was apparent in all animals throughout the first 48 hours after instillation persisting in two at the 72 hour examination; injection of the conjunctival blood vessels was apparent in all cases 24 hours later. Very slight to moderate chemosis was evident in all animals throughout the first 48 hours after instillation persisting in two at the 72 hour examination. Very slight to substantial discharge was also apparent during the first 72 hours after instillation. Scattered or diffuse areas of opacity covering up to half the corneal surface were apparent in all animals 24 hours after instillation, persisting in one animal at the 48 hour examination and in the remaining animal at the 72 hour observation. The treated eye of each animal was overtly normal 15 days after instillation.
Justification for selection of skin irritation / corrosion endpoint:
A well conducted study performed under GLP in accordance with a recognised guideline.
Justification for selection of eye irritation endpoint:
A well conducted study performed under GLP in accordance with a recognised guideline.
Effect level: empty Endpoint conclusion: Adverse effect observed
Justification for classification or non-classification
Skin irritation
In a dermal irritation study all animals showed zero effects (zero score) throughout the period of the study.
MPP is therefore not classified for skin irritation/corrosion under CLP Regulation No. 1272/2008.
Eye irritation
In an acute eye irritation study conducted on MPP with rabbits, at least 2 out of 3 animals showed a conjunctival redness score ≥2 and an oedema (chemosis) score ≥2 which was reversible within 21 days. Calculated as the mean scores following grading at 24, 48 and 72 hours after instillation of the test material.
MPP is therefore classified under CLP Regulation No. 1272/2008 as Irritating to eyes, Category 2.
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